In sigven/oncoEnrichR: Cancer-dedicated gene set interpretation

Drug associations

Each protein/protein in the query set is annotated with:
Molecularly targeted drugs (i.e. small molecule inhibitors/antagonists or monoclonal antibodies), as found through the Open Targets Platform and the NCI Thesaurus
Drugs are organized into the following buckets:
- Targeted cancer drugs in early clinical development/phase (phase 1-2)(column drugs_early_phase)
- Targeted cancer drugs in late clinical development/phase (phase 3-4) (column drugs_late_phase)
- Approved drugs - here also showing the (cancer type) indications for which the drugs are approved for

htmltools::br()
DT::datatable(onc_enrich_report[['data']][['drug']][['target_drugs']], escape = F, 
              extensions=c("Buttons","Responsive"), width = "100%",
              options=list(buttons = c('csv','excel'),dom = 'Bfrtip'))

cat('\n <ul><li>  <i> <span style="font-size: 105%; padding: 3px; background-color:#989898; color:white">&nbsp;&nbsp;<b>NO</b> query proteins with cancer drug associations from Open Targets Platform were found. &nbsp;&nbsp; </span></i></li></ul>',sep='\n')
cat('\n')
cat('<br><br>')

Target tractabilities {.tabset }

Each gene/protein in the query set is annotated with target tractability information (also known as druggability) towards small molecules/compounds and antibodies
Query genes are colored in varying shades of purple (from unknown tractability to clinical precedence )

Small molecules/compounds

htmltools::br()
DT::datatable(onc_enrich_report[['data']][['drug']][['tractability_sm']], escape = F, 
              extensions=c("Buttons","Responsive"), width = "100%",
              options=list(buttons = c('csv','excel'), dom = 'Bfrtip')) |>
   DT::formatStyle(
    "SM_tractability_category", 
    color = "white",
    backgroundColor = DT::styleEqual(
      onc_enrich_report[["config"]][["drug"]][["sm_levels"]],
      onc_enrich_report[["config"]][["drug"]][["sm_levels_colors"]]
    )
  )

Antibodies

htmltools::br()
DT::datatable(onc_enrich_report[['data']][['drug']][['tractability_ab']], escape = F, 
              extensions=c("Buttons","Responsive"), width = "100%",
              options=list(buttons = c('csv','excel'), dom = 'Bfrtip')) |>
   DT::formatStyle(
    "AB_tractability_category", 
    color = "white",
    backgroundColor = DT::styleEqual(
      onc_enrich_report[["config"]][["drug"]][["ab_levels"]],
      onc_enrich_report[["config"]][["drug"]][["ab_levels_colors"]]
    )
  )

{.unlisted .unnumbered .toc-ignore}

Citation Note : If you use the output of the Drug associations module of oncoEnrichR in your research, please cite the following resources and tools: