data-raw/TRRUST/README.md

In slowkow/tftargets: Human Transcription Factor Targets

INTRUDUCTION

TRRUST is a manually curated database of human transcriptional regulatory network.

Current version of TRRUST contains 8,015 transcriptional regulatory relationships between 748 human transcription factors (TFs) and 1,975 non-TF genes, derived from 6,175 pubmed articles, which describe small-scale experimental studies of transcriptional regulations. To efficiently search for regulatory relationships from over 20 million pubmed articles, we used sentence-based text mining approach.

TRRUST database also provide information of mode of regulation (activation or repression). Currently 4,861 (60.6%) regulatory relationships are known for mode of regulation.

Tables for 748 human TFs and 1,975 non-TF genes included in TRRUST.

TRRUST network edge information is freely available for non-commercial research at Download page.

DATA FORMAT

Columns:

1. Transcription Factor
2. Target Gene
3. Relationship (activation, repression, unknown)
4. PubMed Identifiers describing the interaction

Updates

2014.06.24 TRRUST website launched

How to cite TRRUST

TRRUST: A reference database of human transcriptional regulatory interactions. Scientific Reports 5:11432 12 Jun, 2015 http://www.ncbi.nlm.nih.gov/pubmed/?term=26066708

Licencing

Contents of this database are freely available for academia and public entities. If you are a commmercial entitiy, please send an email for further information about licensing.

Contact information

Insuk Lee (Email : insuklee (at) yonsei.ac.kr)

Funding

This work was supported by the National Research Foundation of Korea grant (2010-0017649, 2012M3A9B4028641, 2012M3A9C7050151).

slowkow/tftargets documentation built on May 30, 2019, 3:06 a.m.