TRRUST is a manually curated database of human transcriptional regulatory network.
Current version of TRRUST contains 8,015 transcriptional regulatory relationships between 748 human transcription factors (TFs) and 1,975 non-TF genes, derived from 6,175 pubmed articles, which describe small-scale experimental studies of transcriptional regulations. To efficiently search for regulatory relationships from over 20 million pubmed articles, we used sentence-based text mining approach.
TRRUST database also provide information of mode of regulation (activation or repression). Currently 4,861 (60.6%) regulatory relationships are known for mode of regulation.
Tables for 748 human TFs and 1,975 non-TF genes included in TRRUST.
TRRUST network edge information is freely available for non-commercial research at Download page.
Columns:
2014.06.24 TRRUST website launched
TRRUST: A reference database of human transcriptional regulatory interactions. Scientific Reports 5:11432 12 Jun, 2015 http://www.ncbi.nlm.nih.gov/pubmed/?term=26066708
Contents of this database are freely available for academia and public entities. If you are a commmercial entitiy, please send an email for further information about licensing.
Insuk Lee (Email : insuklee (at) yonsei.ac.kr)
This work was supported by the National Research Foundation of Korea grant (2010-0017649, 2012M3A9B4028641, 2012M3A9C7050151).
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