This function performs very crude mutation calling based on BAFs. The calling is depends only on fold change and minimum AF thresholds.
1 2 | callBafChanges(baftable, cref, csample, foldchange = 1.2, maxref = 0.05,
minAF = 0.15)
|
baftable |
data.frame with variants and allelic frequencies |
cref |
identifier for column with reference BAF (e.g. normal tissue) |
csample |
identifier for column with matched sample BAF (e.g. tumor tissue) |
foldchange |
minimum fold.change threshold to call mutation |
maxref |
numeric, maximum allowed BAF in the reference sample |
minAF |
numeric, minimum BAF required in the sample |
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