logan.plot: Logan plot implementation

Description Usage Arguments Details Value References See Also

View source: R/logan.plot.R

Description

Implements a Logan plot, or Logan graphical analysis, a "graphical method of analysis applicable to ligands that bind reversibly to receptors or enzymes requiring the simultaneous measurement of plasma and tissue radioactivities for multiple times after the injection of a radiolabeled tracer is presented".

Usage

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  logan.plot(input.function, tissue, time.start, time.end,
    plot = TRUE, ...)

Arguments

input.function

Input function TAC.

tissue

Tissue TAC.

time.start

Initial acquisition time for each frame.

time.end

Final acquisition time for each frame.

plot

Should the Logan plot be displayed? Defaults to TRUE.

...

Additional parameters passed to the plot function.

Details

Please refer to the documentation of processlinear for implementation details.

Value

Returns a list with three fields: kparms, the computed kinetic parameters; stderrors, the standard errors for each parameter as a percentage; fit, the actual fitted object.

References

J. Logan, J. S. Fowler, N. D. Volkow, A. P. Wolf, S. L. Dewey, D. J. Schlyer, R. R. MacGregor, R. Hitzemann, B. Bendriem, and S. J. Gatley, "Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects.," Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, vol. 10, no. 5, pp. 740-7, Sep. 1990.

See Also

patlak.plot.


traceRkinetic documentation built on May 31, 2017, 4:36 a.m.