Reversible one-tissue compartment 82-rubidium model with flow correction

Description

This function implements the one-tissue compartment rubidium-82 model published in [1].

Usage

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  lortie.model(input.function, FLV, flow, k2, time.start,
    time.end, a = 0.77, b = 0.63,
    left.ventricle = input.function,
    interpolation.type = 1)

Arguments

input.function

Input function TAC.

FLV

Fraction of blood (from left ventricle) in myocardium TAC.

flow

Myocardial blood flow.

k2

Rate constant.

time.start

Initial acquisition time for each frame (in minutes).

time.end

Final acquisition time for each frame (in minutes).

a

Parameter a of the Renkin-Crone equation implemented in flow2k1. Defaults to 0.77 [unitless].

b

Parameter b of the Renkin-Crone equation implemented in flow2k1. Defaults to 0.63 [ml/min/g].

left.ventricle

Left ventricle TAC, used for spill-over corretion. Defaults to input.function.

interpolation.type

Interpolation type selection. Passed to interpolate.tac. Defaults to 1.

Value

The TAC resulting of solving the model with the given parameters.

References

[1] M. Lortie, R. S. B. Beanlands, K. Yoshinaga, R. Klein, J. N. Dasilva, and R. a DeKemp, "Quantification of myocardial blood flow with 82Rb dynamic PET imaging.," European journal of nuclear medicine and molecular imaging, vol. 34, no. 11, pp. 1765-74, Nov. 2007.