ILoReg: ILoReg: a tool for high-resolution cell population identification from scRNA-Seq data

ILoReg is a tool for identification of cell populations from scRNA-seq data. In particular, ILoReg is useful for finding cell populations with subtle transcriptomic differences. The method utilizes a self-supervised learning method, called Iteratitive Clustering Projection (ICP), to find cluster probabilities, which are used in noise reduction prior to PCA and the subsequent hierarchical clustering and t-SNE steps. Additionally, functions for differential expression analysis to find gene markers for the populations and gene expression visualization are provided.

Package details

AuthorJohannes Smolander [cre, aut], Sini Junttila [aut], Mikko S Venäläinen [aut], Laura L Elo [aut]
Bioconductor views Clustering DataRepresentation DifferentialExpression DimensionReduction GeneExpression RNASeq SingleCell Software Transcription Transcriptomics Visualization
MaintainerJohannes Smolander <>
Package repositoryView on Bioconductor
Installation Install the latest version of this package by entering the following in R:
if (!requireNamespace("BiocManager", quietly = TRUE))


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ILoReg documentation built on Nov. 8, 2020, 8:20 p.m.