LineagePulse: Differential expression analysis and model fitting for single-cell RNA-seq data

LineagePulse is a differential expression and expression model fitting package tailored to single-cell RNA-seq data (scRNA-seq). LineagePulse accounts for batch effects, drop-out and variable sequencing depth. One can use LineagePulse to perform longitudinal differential expression analysis across pseudotime as a continuous coordinate or between discrete groups of cells (e.g. pre-defined clusters or experimental conditions). Expression model fits can be directly extracted from LineagePulse.

Package details

AuthorDavid S Fischer [aut, cre], Fabian Theis [ctb], Nir Yosef [ctb]
Bioconductor views CellBasedAssays CellBiology DifferentialExpression GeneExpression ImmunoOncology Sequencing SingleCell Software StatisticalMethod TimeCourse
MaintainerDavid S Fischer <>
Package repositoryView on Bioconductor
Installation Install the latest version of this package by entering the following in R:
if (!requireNamespace("BiocManager", quietly = TRUE))


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LineagePulse documentation built on Nov. 8, 2020, 7:01 p.m.