computeSlope: Return Slope (normalized slope of the drug response curve)...
In PharmacoGx: Analysis of Large-Scale Pharmacogenomic Data

Description Usage Arguments Value Examples

Return Slope (normalized slope of the drug response curve) for an experiment of a pSet by taking its concentration and viability as input.

1	computeSlope(concentration, viability, trunc = TRUE, verbose = TRUE)

`concentration`	[vector] A concentration range that the AUC should be computed for that range. Concentration range by default considered as not logarithmic scaled. Converted to numeric by function if necessary.
`viability`	[vector] Viablities corresponding to the concentration range passed as first parameter. The range of viablity values by definition should be between 0 and 100. But the viabalities greater than 100 and lower than 0 are also accepted.
`trunc`	[binary] A flag that identify if the viabality values should be truncated to be in the range of (0,100)
`verbose`	[boolean] If 'TRUE' the function will retrun warnings and other infomrative messages.

Returns the normalized linear slope of the drug response curve

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dose <- c("0.0025","0.008","0.025","0.08","0.25","0.8","2.53","8") 
viability <- c("108.67","111","102.16","100.27","90","87","74","57")
computeSlope(dose, viability)