geneDrugSensitivity: Calcualte The Gene Drug Sensitivity

In PharmacoGx: Analysis of Large-Scale Pharmacogenomic Data

Description

TODO:: Write a description!

Usage

geneDrugSensitivity(
  x,
  type,
  batch,
  drugpheno,
  interaction.typexgene = FALSE,
  model = FALSE,
  standardize = c("SD", "rescale", "none"),
  verbose = FALSE
)

Arguments

x	A numeric vector of gene expression values
type	A vector of factors specifying the cell lines or type types
batch	A vector of factors specifying the batch
drugpheno	A numeric vector of drug sensitivity values (e.g., IC50 or AUC)
interaction.typexgene	boolean Should interaction between gene expression and cell/type type be computed? Default set to FALSE
model	boolean Should the full linear model be returned? Default set to FALSE
standardize	character One of 'SD', 'rescale' or 'none'
verbose	boolean Should the function display messages?

Value

A vector reporting the effect size (estimateof the coefficient of drug concentration), standard error (se), sample size (n), t statistic, and F statistics and its corresponding p-value.

PharmacoGx documentation built on Feb. 28, 2021, 2 a.m.