gwc: GWC Score

In PharmacoGx: Analysis of Large-Scale Pharmacogenomic Data

Description

Calculate the gwc score between two vectors, using either a weighted spearman or pearson correlation

Usage

gwc(
  x1,
  p1,
  x2,
  p2,
  method.cor = c("pearson", "spearman"),
  nperm = 10000,
  truncate.p = 1e-16,
  ...
)

Arguments

x1	numeric vector of effect sizes (e.g., fold change or t statitsics) for the first experiment
p1	numeric vector of p-values for each corresponding effect size for the first experiment
x2	numeric effect size (e.g., fold change or t statitsics) for the second experiment
p2	numeric vector of p-values for each corresponding effect size for the second experiment
method.cor	character string identifying if a pearson or spearman correlation should be used
nperm	numeric how many permutations should be done to determine
truncate.p	numeric Truncation value for extremely low p-values
...	Other passed down to internal functions

Value

numeric a vector of two values, the correlation and associated p-value.

Examples

data(CCLEsmall)
x <- molecularProfiles(CCLEsmall,"rna")[,1]
y <- molecularProfiles(CCLEsmall,"rna")[,2]
x_p <- rep(0.05, times=length(x))
y_p <- rep(0.05, times=length(y))
names(x_p) <- names(x)
names(y_p) <- names(y)
gwc(x,x_p,y,y_p, nperm=100)

PharmacoGx documentation built on Feb. 28, 2021, 2 a.m.