Krogan: High-Definition Macromolecular Composition of Yeast...

In apComplex: Estimate protein complex membership using AP-MS protein data

Description

AP-MS data published by Krogan et al. (2004)

Usage

data(Krogan)

Details

Krogan is a matrix of the AP-MS data published by Krogan et al (2004). The 153 rows correspond to bait proteins and the 485 columns correspond to proteins found as hits in the AP-MS experiment and are named accordingly. The first 153 column names are the same as the 153 row names; bait proteins can also be found as hits by other baits, hence their inclusion as columns in Krogan. An entry of "1" in the ith row and jth column of Krogan indicates that bait protein i found protein j as a hit. All other entries are "0". There are a total of 1132 "1" entries in the matrix, corresponding to the 1132 comemberships detected in the experiment.

These data are available at http://www.molecule.org/cgi/content/full/13/2/225/DC1/.

Source

Krogan, et al. High-Definition Macromolecular Composition of Yeast RNA-Processing Complexes; Molecular Cell, Vol 13, 225-239, 30 January 2004.

References

Scholtens D and Gentleman R. Making sense of high-throughput protein-protein interaction data. Statistical Applications in Genetics and Molecular Biology 3, Article 39 (2004).

Scholtens D, Vidal M, and Gentleman R. Local modeling of global interactome networks. Bioinformatics 21, 3548-3557 (2005).

See Also

MBMEcKrogan

Examples

data(Krogan)

apComplex documentation built on Nov. 8, 2020, 7:43 p.m.