Affiliation matrices with rows corresponding to proteins and columns corresponding to complexes.
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These are the results from an analysis of the HMS-PCI data (Ho et al., 2002)
described by Scholtens and Gentleman (2004) and Scholtens, Vidal, and
Gentleman (submitted). These
estimates were constructed using
findComplexes with a sensitivity
parameter of .75, specificity of .99, and Beta=-0.2 for externally derived
similarity measure based on Gene Ontology cellular component annotation (see
Scholtens and Gentleman (2004)).
MBMEcHMSPCI contains 242 multi-bait-multi-edge complex estimates.
SBMHcHMSPCI contains 437 single-bait-multi-hit complex estimates.
UnRBBcHMSPCI contains 329 unreciprocated bait-bait complex
estimates. These data are also available at
Scholtens D and Gentleman R. Making sense of high-throughput protein-protein interaction data. Statistical Applications in Genetics and Molecular Biology 3, Article 39 (2004).
Scholtens D, Vidal M, and Gentleman R. Local modeling of global interactome networks. Bioinformatics 21, 3548-3557 (2005).
Ho, et al. Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature 415, 180-183 (2002).
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