Makes pseudo-inferential replicate counts from
variance assays. The simulated
counts are drawn from a negative binomial distribution,
size set using a method
of moments estimator for dispersion.
makeInfReps(y, numReps, minDisp = 0.001)
how many inferential replicates
the minimal dispersion value, set after method of moments estimation from inferential mean and variance
Note that these simulated counts only reflect marginal
variance (one transcript or gene at a time),
and do not capture the covariance of counts across
transcripts or genes, unlike imported inferential
replicate data. Therefore,
not be used with
summarizeToGene to create
gene-level inferential replicates if inferential
replicates were originally created on the transcript
level. Instead, import the original inferential
Van Buren, S., Sarkar, H., Srivastava, A., Rashid, N.U., Patro, R., Love, M.I. (2020) Compression of quantification uncertainty for scRNA-seq counts. bioRxiv. https://doi.org/10.1101/2020.07.06.189639
1 2 3 4 5
Add the following code to your website.
For more information on customizing the embed code, read Embedding Snippets.