Description Usage Arguments Details Value Examples
Due to the nature of the Hipathia method, the length of a pathway may influence its signal rank. In order to compare signal values among subpathways, we strongly recommend to normalize the matrix with this normalization.
1 | normalize_paths(path_vals, metaginfo)
|
path_vals |
SummarizedExperiment or matrix of the pathway values |
metaginfo |
Pathways object |
This function removes the bias caused by the length of the subpathways by dividing by the value obtained from running the method with a basal value of 0.5 at each node.
SummarizedExperiment or matrix of normalized pathway values,
depending on the class of path_vals
.
1 2 3 4 | data(path_vals)
pathways <- load_pathways(species = "hsa", pathways_list = c("hsa03320",
"hsa04012"))
path_normalized <- normalize_paths(path_vals, pathways)
|
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