Most human genes have multiple promoters that control the expression of different isoforms. The use of these alternative promoters enables the regulation of isoform expression pre-transcriptionally. Alternative promoters have been found to be important in a wide number of cell types and diseases. proActiv is an R package that enables the analysis of promoters from RNA-seq data. proActiv uses aligned reads as input, and generates counts and normalized promoter activity estimates for each annotated promoter. In particular, proActiv accepts junction files from TopHat2 or STAR or BAM files as inputs. These estimates can then be used to identify which promoter is active, which promoter is inactive, and which promoters change their activity across conditions.
|Author||Deniz Demircioglu [aut] (<https://orcid.org/0000-0001-7857-0407>), Jonathan Göke [aut], Joseph Lee [cre]|
|Bioconductor views||AlternativeSplicing DifferentialSplicing Epigenetics FunctionalGenomics GeneExpression GeneRegulation Preprocessing RNASeq Transcription Transcriptomics|
|Maintainer||Joseph Lee <firstname.lastname@example.org>|
|License||MIT + file LICENSE|
|Package repository||View on Bioconductor|
Install the latest version of this package by entering the following in R:
Any scripts or data that you put into this service are public.
Add the following code to your website.
For more information on customizing the embed code, read Embedding Snippets.