Description Usage Arguments Details Value Author(s) References See Also Examples
This function compares two hazard ratios from their betas and standard errors as computed by a Cox model for instance. The statistical test is a Student t test for dependent samples. The two hazard ratios must be computed from the same survival data.
1 | hr.comp2(x1, beta1, se1, x2, beta2, se2, n)
|
x1 |
risk score used to estimate the first hazard ratio. |
beta1 |
beta estimate for the first hazard ratio. |
se1 |
standard error of beta estimate for the first hazard ratio. |
x2 |
risk score used to estimate the second hazard ratio. |
beta2 |
beta estimate for the second hazard ratio. |
se2 |
standard error of beta estimate for the first hazard ratio. |
n |
number of samples from which the hazard ratios were estimated. |
The two hazard ratios must be computed from the same samples (and corresponding survival data). The function uses a Student t test for dependent samples.
p.value |
p-value from the Student t test for the comparison beta1 > beta2 (equivalently hr1 > hr2) |
hr1 |
value of the first hazard ratio |
hr2 |
value of the second hazard ratio |
Benjamin Haibe-Kains
Student 1908) "The Probable Error of a Mean", Biometrika, 6, 1, pages 1–25.
Haibe-Kains, B. and Desmedt, C. and Sotiriou, C. and Bontempi, G. (2008) "A comparative study of survival models for breast cancer prognostication based on microarray data: does a single gene beat them all?", Bioinformatics, 24, 19, pages 2200–2208.
1 2 3 4 5 6 7 8 9 10 11 | set.seed(12345)
age <- as.numeric(rnorm(100, 50, 10) >= 50)
size <- as.numeric(rexp(100,1) > 1)
stime <- rexp(100)
cens <- runif(100,.5,2)
sevent <- as.numeric(stime <= cens)
stime <- pmin(stime, cens)
coxm1 <- coxph(Surv(stime, sevent) ~ age)
coxm2 <- coxph(Surv(stime, sevent) ~ size)
hr.comp2(x1=age, beta1=coxm1$coefficients, se1=drop(sqrt(coxm1$var)),
x2=size, beta2=coxm2$coefficients, se2=drop(sqrt(coxm2$var)), n=100)
|
Loading required package: survival
Loading required package: prodlim
$p.value
age
0.1378236
$hr1
age
1.252962
$hr2
size
0.8363489
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