CRISPR Pooled Screen Analysis using Beta-Binomial Test

calc_mappability | A function to calculate the mappabilities of each NGS sample. |

Evers_CRISPRn_RT112 | A benchmark CRISPRn pooled screen data from Evers et al. |

fit_ab | A C++ function to perform a parameter estimation for the... |

get_CPM | A function to normalize sgRNA read counts. |

join_count_and_design | A function to join a count table and a design table. |

measure_gene_stats | A function to perform gene-level test using a sgRNA-level... |

measure_sgrna_stats | A function to perform a statistical test at a sgRNA-level |

plot_corr_heatmap | A function to show a heatmap sgRNA-level corrleations of the... |

plot_count_distribution | A function to plot read count distribution. |

plot_dotplot | A function to visualize dot plots for a gene. |

plot_PCA | A function to plot the first two principal components of... |

quant | A C++ function to quantify sgRNA abundance from NGS samples. |

run_estimation | A function to perform a statistical test at a sgRNA-level,... |

run_sgrna_quant | A function to run a sgRNA quantification algorithm from NGS... |

Sanson_CRISPRn_A375 | A benchmark CRISPRn pooled screen data from Sanson et al. |

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