CHAT is a collection of methods developed for researchers in the field of cancer genomics to study the intra-heterogeneity of tumors. It is applied on both high-density SNP array data and next generation sequencing data. CHAT estimates tumor purity, ploidy on the genome-wide level. It can also assign each somatic CNA or mutation its fraction of cancer cell carriers, namely, sAGP or CCF.
Bo Li <[email protected]>
Li et al., Genomic estimates of aneuploid content in Glioblastoma Multiforme and imporved classification. _Clinical Cancer Research_, 2012.
Li et al., A general framework for characterizing tumor subclonality using DNA sequencing and SNP array data. 2014. Submitted to Genome Biology.
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