CHAT-package: Clonal Heterogeneity Analysis Tool

Description Details Author(s) References


CHAT is a collection of methods developed for researchers in the field of cancer genomics to study the intra-heterogeneity of tumors. It is applied on both high-density SNP array data and next generation sequencing data. CHAT estimates tumor purity, ploidy on the genome-wide level. It can also assign each somatic CNA or mutation its fraction of cancer cell carriers, namely, sAGP or CCF.


Package: CHAT
Type: Package
Version: 1.0
Date: 2014-02-10
License: GPL(>=2)


Bo Li <[email protected]>


Li et al., Genomic estimates of aneuploid content in Glioblastoma Multiforme and imporved classification. _Clinical Cancer Research_, 2012.

Li et al., A general framework for characterizing tumor subclonality using DNA sequencing and SNP array data. 2014. Submitted to Genome Biology.

CHAT documentation built on May 29, 2017, 10:32 p.m.