calculate_confidence_limit_values: Calculate the value of confidence limit

In HaDeX2: Analysis and Visualisation of Hydrogen/Deuterium Exchange Mass Spectrometry Data

Calculate the value of confidence limit

Description

Calculates confidence limit values for prepared provided, based on chosen parameters.

Usage

calculate_confidence_limit_values(
  diff_uptake_dat,
  confidence_level = 0.98,
  theoretical = FALSE,
  fractional = TRUE,
  n_rep = NULL
)

Arguments

diff_uptake_dat	differential data calculated using calculate_diff_uptake function
confidence_level	confidence level for the test, from range [0, 1]
theoretical	logical, determines if values are theoretical
fractional	logical, determines if values are fractional
n_rep	number of replicates

Details

Function calculate_confidence_limit_values calculates confidence limit using Houde test. The confidence limits are calculated on whole provided dataset. If the user wishes to calculate confidence limit for one, two or more time points, the provided data should be adjusted accordingly.

Value

range of confidence limit interval

References

Houde, D., Berkowitz, S.A., and Engen, J.R. (2011). The Utility of Hydrogen/Deuterium Exchange Mass Spectrometry in Biopharmaceutical Comparability Studies. J Pharm Sci 100, 2071–2086.

See Also

read_hdx calculate_diff_uptake create_diff_uptake_dataset

Examples

diff_uptake_dat <- calculate_diff_uptake(alpha_dat)
calculate_confidence_limit_values(diff_uptake_dat)
                              

HaDeX2 documentation built on Feb. 9, 2026, 5:07 p.m.