LncPath: Identifying the Pathways Regulated by LncRNA Sets of Interest

Identifies pathways synergisticly regulated by the interested lncRNA(long non-coding RNA) sets based on a lncRNA-mRNA(messenger RNA) interaction network. 1) The lncRNA-mRNA interaction network was built from the protein-protein interactions and the lncRNA-mRNA co-expression relationships in 28 RNA-Seq data sets. 2) The interested lncRNAs can be mapped into networks as seed nodes and a random walk strategy will be performed to evaluate the rate of each coding genes influenced by the seed lncRNAs. 3) Pathways regulated by the lncRNA set will be evaluated by a weighted Kolmogorov-Smirnov statistic as an ES Score. 4) The p value and false discovery rate value will also be calculated through a permutation analysis. 5) The running score of each pathway can be plotted and the heat map of each pathway can also be plotted if an expression profile is provided. 6) The rank and scores of the gene list of each pathway can be printed.

AuthorJunwei Han, Zeguo Sun
Date of publication2016-05-16 14:45:44
MaintainerJunwei Han <hanjunwei1981@163.com>
LicenseGPL (>= 2)
Version1.0

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Files in this package

LncPath
LncPath/inst
LncPath/inst/doc
LncPath/inst/doc/LncPath.R
LncPath/inst/doc/LncPath.pdf
LncPath/inst/doc/LncPath.Rnw
LncPath/NAMESPACE
LncPath/data
LncPath/data/datalist
LncPath/data/LncPathEnvir.rda
LncPath/R
LncPath/R/inner.r
LncPath/R/getExampleData.r
LncPath/R/findSigGenes.r
LncPath/R/lncPath.r
LncPath/R/getNet.r
LncPath/R/resultHandling.r
LncPath/vignettes
LncPath/vignettes/LncPath.Rnw
LncPath/MD5
LncPath/build
LncPath/build/vignette.rds
LncPath/DESCRIPTION
LncPath/man
LncPath/man/drawAHeatMap.Rd LncPath/man/getExampleData.Rd LncPath/man/printSignifResult.Rd LncPath/man/getNet.Rd LncPath/man/LncPathEnvir.Rd LncPath/man/geneSetDetail.Rd LncPath/man/lncPath.Rd LncPath/man/LncPath-internal.Rd LncPath/man/plotRunningES.Rd LncPath/man/findSigGenes.Rd LncPath/man/lncPath2Table.Rd

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