nnls_deconv: Estimate cell type relative proportion

In MethScope: Ultra-Fast Analysis of Sparse DNA Methylome via Recurrent Pattern Encoding

Estimate cell type relative proportion

Description

Estimate cell type relative proportion

Usage

nnls_deconv(ref, mixture_matrix, number_patterns = 1000, var_threshold = 0.01)

Arguments

ref	An imputed wide cell by pattern matrix generated from GenerateInput function using reference Pseudobulk
mixture_matrix	An imputed wide cell by pattern matrix generated from GenerateInput function
number_patterns	a numeric value to indicate number of patterns to be used (Default: 1000)
var_threshold	a numeric value to indicate variance that should filter the patterns (Default: 0.1)

Value

A cell type by cell matrix showing the relative cell type proportion estimate for each cells

MethScope documentation built on Feb. 27, 2026, 1:08 a.m.