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# Algorithm for j0 estimation based on the method of Hall and Schimek (2012)
# The algorithm consists of an ordered sequence of "test stages" s1, s2, ....
# Stage sk is associated with an integer Jsk, which when k is odd, is a potential lower bound to j0
# Idata - input data is a vector of 0's and 1's
calculate.maxK <- function(lists, L, d, v, threshold=50) {
compared.lists <- list() #contains all pairwise compared lists (structure for aggmap)
info <- matrix(ncol = 0, nrow = 3) #contains information about list names
rownames(info) <- c("listname", "original listname", "ref-list or trunc-list")
grayL <- list() #contains information which object in the list has to be gray-shaded
grayO <- c() #contains all gray-shaded objects
temp.sumtrunclists <- list() #contains the summarized truncated lists (number of lists = L)
summarytable <- matrix(nrow = 0, ncol = (3 + L)) #contains the summary-table
venn.values <- list() #contains the Venn-lists for the Venn-diagram and the Venn-table (a Venn-diagram in table form)
cg_temp = c()
#first step: estimate the j_0 (and so k)
res.j0.temp <- j0.multi(lists, d, v)
res.temp <- as.matrix(res.j0.temp$L)
#print(res.temp)
maxK <- res.j0.temp$maxK
if(sum(is.na(res.temp[,5]))<nrow(res.temp)){
tl = as.list(lists[1:maxK, ])
tli = as.character(unique(unlist(tl)))
sp = rep(list(tli),L)
resS = CEMC(input = tl, space = sp, k = maxK)
temp = tapply(as.numeric(res.temp[, 5]), res.temp[, 1], function(x) max(x, na.rm = TRUE))
if (sum(temp!="-Inf")>1){
if (sum(is.na(res.temp[,5]))>0){
res.temp2 = res.temp[-which(is.na(res.temp[,5])),]
} else
{res.temp2 = res.temp}
} else {
if (sum(is.na(res.temp[,5]))>0)
{res.temp2 = t(as.matrix(res.temp[-which(is.na(res.temp[,5])),]))
} else {
res.temp2 = t(as.matrix(res.temp))
}
}
temp2 = tapply(as.numeric(res.temp2[,5]), res.temp2[,1], function(x) max(x, na.rm = TRUE))
list_t = list()
for (i in unique(res.temp2[,1])){
res.temp.temp = res.temp2[res.temp2[,1]==i,]
if(!is.matrix(res.temp.temp)){
res.temp.temp = t(as.matrix(res.temp.temp))
}
list_t[[i]] = cbind(res.temp.temp[,2][order(res.temp.temp[,5], decreasing=T)], res.temp.temp[,5][order(res.temp.temp[,5],decreasing=T)])
}
#Calculating block order(bo)
bo = names(sort(unlist(lapply(list_t, FUN=function(x) max(as.numeric(x[,2]), na.rm=T))), decreasing=T))
ilor = lapply(list_t, FUN=function(x) x[,1][order(as.numeric(x[,2]), decreasing=T)]) #inblock list order
if (length(bo)>1)
{
ilor_final = list() # inblock list order final
ilor_final[[bo[1]]] = ilor[[bo[1]]]
bo_temp = c()
for (i in c(2:length(bo)))
{
bo_temp = c(bo_temp, bo[[i-1]]);
ilor_final[[bo[i]]] = setdiff(ilor[[bo[i]]], bo_temp)
}
}else{ilor_final = ilor}
bo_final = names(ilor_final)[which(lapply(ilor_final, length)!=0)]
##### condition if maximal estimated j0 is NA, then warning is returned #####
if (maxK!="-Inf")
{
###### building plotflow#####
crl <- 0 #current reference list
#iterate over all blocks (a block is a reference list with the corresponding truncation lists)
# fln - first list name
for (fln in bo_final) {
# selecting block
temp2 = list_t[[fln]]
rownames(temp2) = temp2[,1]
#get the objects of the current reference list
gnp <- as.vector(lists[, fln][1:maxK]) # gene names to plot
#gnp <- as.vector(gnp)
crl <- crl + 1
compared.lists[[paste("R", crl, sep = "")]] <- gnp
temp.sumtrunclists[[fln]] <- gnp
info <- cbind(info, c(paste("R", crl, sep = ""), fln, "R"))
ctr <- 0 #current truncated lists
grayL[[paste("R", crl, sep = "")]] <- rep(FALSE, length(gnp))
temp.countgray <- matrix(ncol = 2, nrow = length(gnp), data = 0)
#iterate over the truncated lists of the current block
for (l in c(1:length(ilor_final[[fln]]))) {
n.genes.to.plot <- as.numeric(temp2[ilor_final[[fln]][l],2])
temp.distances = c(1:length(gnp)) - match(gnp, as.character(lists[, ilor_final[[fln]][l]]))
temp.countgray[,2] = temp.countgray[,2]+c(abs(temp.distances)<=d)
##temp.sumtrunclists[[ilor_final[[fln]][l]]] <- lists[, ilor_final[[fln]][l]][1:(as.numeric(temp2[ilor_final[[fln]][l],2]))]
temp.sumtrunclists[[ilor_final[[fln]][l]]] <- lists[, ilor_final[[fln]][l]][1:length(resS$TopK)]
##check for gray-shade of an object in the truncated list
temp.grayshade = abs(temp.distances)<=d
##add the truncated list
ctr <- ctr + 1
compared.lists[[paste("R", crl, "_T", ctr, sep = "")]] <- temp.distances
grayL[[paste("R", crl, "_T", ctr, sep = "")]] <- temp.grayshade
info <- cbind(info, c(paste("R", crl, "_T", ctr, sep = ""), ilor_final[[fln]][l], "T"))
}# end for l
#calculate if respective object of the reference list has to be gray-shaded
temp.percentage = apply(as.matrix(temp.countgray[,-1]),1,sum)/c(length(ilor_final[[fln]]))*100
grayL[[paste("R", crl, sep = "")]] = temp.percentage >= threshold
#add object to a new list which contains all gray-shaded objects (add only if it is not already in the list)
grayO = union(grayO, lists[, fln][which(temp.percentage >= threshold)])
}# end for fln
#having all the necessary information, calculate the summary-table
colnames(summarytable) <- c(names(lists), "Rank sum", "Freq in input lists", "Freq in truncated lists")
for (j in 1:length(tli)) {
cg <- tli[j] #current genesymbol
#get the positions of the current object in the input lists
temp.positions <- rep(NA,L)
for (q in 1:L) {
temp.positions[q] <- match(cg, lists[,names(lists)[q]])
}#end for q
#### positions = apply(lists,2,FUN=function(x) match(tli,x))
#calculate the rank sum
temp.ranksum <- 0
temp.missingvalues <- 0
for (q in 1:L) {
if (is.na(temp.positions[q])) {
temp.missingvalues <- temp.missingvalues + 1
}
}#end for q
#if one or more rank positions are unavaliable (e.g. an object does not exist in a list), interpolate the rank sum
if (temp.missingvalues > 0) {
temp.meanrank <- 0
temp.partialranksum <- 0
#get the rank sum of the valid rank-positions
for (q in 1:L) {
if (!is.na(temp.positions[q])) {
temp.partialranksum <- temp.partialranksum + temp.positions[q]
}
}#end for q
#calculate the mean rank-position for the unavailable rank-positions
temp.meanrank <- round(temp.partialranksum / (L - temp.missingvalues))
temp.ranksum <- temp.partialranksum + (temp.meanrank * temp.missingvalues)
} else {
temp.ranksum <- sum(temp.positions)
}# end if temp.missingvalues
#calculate the frequency in the input lists
temp.freqinput <- L - temp.missingvalues
#calculate the frequency in the summarized truncated lists
temp.freqtrunc <- 0
for (curr.listname in names(temp.sumtrunclists)) {
if (cg %in% temp.sumtrunclists[[curr.listname]]) {
temp.freqtrunc <- temp.freqtrunc + 1
}
}
#add the calculated row (of the current object) to the summary-table
cg_temp = c(cg_temp, cg)
summarytable <- rbind(summarytable, c(temp.positions, temp.ranksum, temp.freqinput, temp.freqtrunc))
}# end for j
## calculate Venn table
# changing into vectors of characters
temp.sumtrunclists.vect <- sapply(temp.sumtrunclists,as.vector, simplify=FALSE)
names(temp.sumtrunclists.vect) <- names(temp.sumtrunclists)
#check for each object if entry is present in lists
venn.table <- data.frame(do.call(cbind, lapply(na.exclude(names(temp.sumtrunclists.vect)), function(nn){
ifelse(tli %in% as.vector(temp.sumtrunclists.vect[[nn]]),nn,NA)
})), stringsAsFactors=FALSE)
rownames(venn.table) <- tli
venn.table$listname <-apply(venn.table, 1, function(x){paste(sort(x[!is.na(x)]), sep="", collapse="_")})
venn.temp <- split(rownames(venn.table),venn.table$listname)
# adding stars to those that were in the CEMC final list
venn.list <- lapply(venn.temp, function(x) {a = rep("*",length(x))[match(x,resS$TopK)>0]; a[which(is.na(a))]=""; paste(a,x,sep="")})
venn.list <- venn.list[order(-sapply(names(venn.list), nchar), names(venn.list))]
venntable <- data.frame(t(sapply(names(venn.list), function(nn){
data.frame(intersection=nn,objects=paste(sort(venn.list[[nn]]), sep="",collapse=", "), stringsAsFactors=FALSE)
})))
rownames(venntable) <- NULL
#conversion of the summary table into a data frame so that the rankings are given as numbers, not as characters, otherwise the ordering is wrong
summarytable.temp = data.frame(Object=cg_temp,summarytable, stringsAsFactors=FALSE)
TopKranks = data.frame(TopK=resS$TopK, ranks=1:length(resS$TopK))
CEMCres = rep("",nrow(summarytable.temp))
CEMCres[match(TopKranks$TopK,summarytable.temp$Object)] = "YES"
summarytable.temp2 = data.frame(Final.selection.CEMC = CEMCres, summarytable.temp)
topk.table = summarytable.temp2[which(summarytable.temp2$Final.selection.CEMC=='YES'),]
ranks = numeric()
ranks[match(TopKranks$TopK,topk.table$Object)] = TopKranks$ranks
topk.table.rank = topk.table[order(ranks),]
rest.table = summarytable.temp2[which(summarytable.temp2$Final.selection.CEMC==''),]
rest.table = rest.table[order(rest.table[,L+3]),]
summarytable.final = rbind(topk.table.rank, rest.table)
#calculate the Venn-lists (to view the Venn-diagram) and the Venn-table
#the calculation takes place only for L between 2 and 4 (a Venn-diagram for L > 4 cannot be properly arranged)
##combine all necessary objects into one single list
truncated.lists <- list()
truncated.lists$comparedLists <- compared.lists
truncated.lists$info <- info
truncated.lists$grayshadedLists <- grayL
truncated.lists$summarytable <- summarytable.final
truncated.lists$vennlists <- temp.sumtrunclists
truncated.lists$venntable <- venntable
truncated.lists$v <- v
truncated.lists$Ntoplot<-sum(unlist(lapply(ilor_final,length)))+sum(unlist(lapply(ilor_final,length))>0)
truncated.lists$Idata <- res.j0.temp$Idata
truncated.lists$d <- d
truncated.lists$threshold <- threshold
truncated.lists$L <- L
truncated.lists$N <- nrow(lists)
truncated.lists$lists <- lists
truncated.lists$maxK <-maxK
truncated.lists$topkspace <-resS$TopK
return(truncated.lists)
}
} else {
message(paste("!!!...For selected delta, the top L list cannot be estimated (little or no overlap)!!!", "\n"))
return(truncated.lists=NULL)
} # end if if (maxK)
}# end of function calculate.maxK
compute.stream<-function(Idata, const=0.251, v, r=1.2)
{
if(sum(Idata, na.rm=T)==length(Idata))
{
return(list(j0_est=length( ), reason.break="Idata is identity", Js=NA, v=v))
}else
{
zv = .moderate.deviation(const, v)
Js = c()
k = 1
pj.plus = c()
pj.minus = c()
h = 0
reason.break="NA"
###########
repeat
{
if (floor(k/2)<(k/2))
{
if (k==1)
{ h = 1;
j=h-1;
v.last=v[k]
if (j< length(Idata))
{
repeat
{
j = j+1
if ((j+v[k]-1) >= length(Idata)) {#print("(j+v[k]-1) >= length(Idata)")
break}
# computing pjplus
pj.plus = .pjplus(Idata, v[k], j)
#print(pj.plus)
#print(Idata[j:(j+v[k]-1)])
# testing
if ((pj.plus-0.5)<=zv) {#print("pj.plus-0.5<=zv")
break}
}#end repeat
Js[k] = j
Js
if(reason.break!="NA"){break;}
}# end if j<length(Idata)
} else{
h = Js[k-1]-trunc(r*v.last)+1;
j = h-1;
#print(paste("j=",j, sep=""))
if (j< length(Idata))
{
repeat
{
j = j+1
if ((j+v.last-1) >= length(Idata)) {break}
# computing pjplus
pj.plus = .pjplus(Idata, v.last, j)
# testing
if ((pj.plus-0.5)<=zv) {break}
}
if(reason.break!="NA"){break;}
Js[k] = j
Js
# breaking the repeat loop condition 2
if ((k-3)>=1) {if (Js[k-2]==Js[k] & Js[k-1]==Js[k-3]) {reason.break="Js[i-2]==Js[i] & Js[i-1]==Js[i-3]";
break}
}
}# end if
}#end else
} # end is.odd
if ((floor(k/2)==(k/2)))
{
h = Js[k-1]+trunc(r*v.last)
j = h
if (j>1)
{
repeat
{
j = j-1
# computing pjminus
if ((j-v.last+1) <= 0){break}
pj.minus = .pjminus(Idata, v.last, j)
# testing
if ((pj.minus-0.5)>zv) {break}
}# end repeat
Js[k] = j
# breaking the repeat loop condition 3
if (Js[k]-trunc(r*v.last)+1<=1) { v.temp=v.last;
while((Js[k]-r*v.temp<=1) & v.temp>0){v.temp=v.temp-1}
v.last=v.temp}
if (v.last==1){reason.break = "v converged to 1"; v[k+1]=v.last ;break; }
if (v.last==0){reason.break = "v converged to 0"; v[k+1]=v.last ;break; }
# breaking the repeat loop condition 1
if (is.infinite(Js[k-1]) & is.infinite(Js[k]))
{reason.break="is.infinite(Js[i-1]) & is.infinite(Js[i])"; break}
} # end if
if(reason.break!="NA"){break;}
}
k=k+1
v[k]=v.last
}#end repeat
if(v.last<=1 | reason.break!="Js[i-2]==Js[i] & Js[i-1]==Js[i-3]"){j0_est=NA} else {if ((floor(k/2)<(k/2)) & k>2) {j0_est = ceiling(Js[k-2]+0.5*v[k-2])}else if ((floor(k/2)==(k/2)) & k>1){j0_est = ceiling(Js[k-1]+0.5*v[k-1])} else{j0_est=NA}}
return(list(j0_est=j0_est+1, k=j0_est, reason.break=reason.break, Js=Js+1, v=v))
}# end if sum(Idata)==length(Idata)
}
#Method of Hall and Schimek (2012) adapted to the situation of multiple ranked lists
#Inputs:
#Data - input matrix, each column represents one list
#delta - the maximal distance between the rank positions of an object in a pair of lists
#v - value of tuning parameter nu used for j0 estimation
#Outputs: maximal estimated j0 based on all combinations of 2 lists
#Data = lists
#delta between 0 and 20 suggested for short lists with N<200
#v=10 suggested for short lists with N<200
j0.multi<-function(lists,d,v) {
if(is.null(colnames(lists))){
colnames(lists)<-paste("L",1:ncol(lists),sep="")
warning("No colnames given in lists. Replaced with default values: L1, L2...")
}
maxK=0
L = c()
Idata_ID = c()
names_idata = c()
for (i in 1:ncol(lists)){
for (j in 1:ncol(lists)){
if (i!=j) {
ID = prepare.idata(lists[,c(i,j)],d=d)
Idata_ID=cbind(Idata_ID, ID$Idata)
names_idata = c(names_idata, paste(colnames(lists)[i],"_",colnames(lists)[j],sep=""))
J = compute.stream(ID$Idata,v=v)$j0_est
k = compute.stream(ID$Idata,v=v)$k
L = rbind(L, cbind(colnames(lists)[i], colnames(lists)[j], v,J,k, d))
}# end for if
}# end for j
}# end for i
colnames(Idata_ID) = names_idata
L = data.frame(L, stringsAsFactors=F)
names(L) = c("list1", "list2", "v", "j0_est","k","delta")
if(sum(is.na(L$k))<nrow(L)){maxK = max(as.numeric(L$k), na.rm=T)}else{maxK=NA}
return(list(maxK=maxK,L=L, Idata=Idata_ID))
}
# Zv moderate deviation
.moderate.deviation <- function(C, v)
{
zv = sqrt((C*log(v, base=10))/v)
return(zv)
}
.pjminus <- function(Idata, v, j)
{
pj.minus = 1/v*(sum(Idata[(j-v+1):j], na.rm = TRUE))
return(pj.minus)
}
.pjplus <- function(Idata, v, j)
{
pj.plus = (1/v)*(sum(Idata[j:(j+v-1)], na.rm = TRUE))
return(pj.plus)
}
# Function to prepare Idata for multiple rankings from several assessors allowing for missing values
# x - data matrix, where columns represent the rank order of objects from two different assessors and the rows represent object names
# delta - the maximal distance between the rank positions of an object in a pair of lists
# num.omit - the maximal number of ommited objects from the analysis
#
# The result is an object of type "Idata", which is a list containing Idata and the information on the distance delta.
prepare.idata <- function(x, d)
{
if(ncol(x)<2){
warning("You need a minimum of two lists to compare. Execution halted.","\n")
}else{
if(ncol(x)>2){warning("The data matrix you have submitted contains more than two lists (columns). Only first two will be used.","\n")}
rank.diff = c(1:nrow(x))-match(x[,1],x[,2])
Idata = as.numeric(abs(rank.diff)<=d)
Idata[is.na(Idata)] = 0
return(list(Idata = Idata, d = d))
}
}
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