UBCRM: Functions to Simulate and Conduct Dose-Escalation Phase I Studies

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Two Phase I designs are implemented in the package: the classical 3+3 and the Continual Reassessment Method. Simulations tools are also available to estimate the operating characteristics of the methods with several user-dependent options.

Author
Benjamin Esterni with contribution from Baboukar Mane
Date of publication
2015-02-20 10:31:31
Maintainer
Christophe Zemmour <zemmourc@ipc.unicancer.fr>
License
GPL (>= 2)
Version
1.0.1

View on CRAN

Man pages

aip
Functions to calculate the appropriate dose level singletons
CreData
Creates a CRM dataframe
Crm
Dose-escalation with the Continual Reassessment Method
fp
Density functions
Lp
Likelihood functions
psip
Dose-Toxicity modelisation functions
sim3p3
Simulation of one dose-escalation study with the classical...
simCrm
Simulation of one dose-escalation study with the Continual...
ssim3p3
Simulation of n dose-escalation study with the 3+3 design
ssimCrm
Simulation of n dose-escalation study with the Continual...
troisPtrois
Dose escalation with the 3+3 design
UBCRM-package
UBCRM is a package containing functions to simulate and...
updata
Update the CRM dataframe after new patients' collected data

Files in this package

UBCRM
UBCRM/inst
UBCRM/inst/NEWS
UBCRM/NAMESPACE
UBCRM/R
UBCRM/R/Lp.R
UBCRM/R/psip.R
UBCRM/R/aip.R
UBCRM/R/ssim3p3.R
UBCRM/R/sim3p3.R
UBCRM/R/ait1.R
UBCRM/R/ait2.R
UBCRM/R/update.R
UBCRM/R/ail2.R
UBCRM/R/simCrm.R
UBCRM/R/CreData.R
UBCRM/R/troisPtrois.R
UBCRM/R/psit.R
UBCRM/R/ail1.R
UBCRM/R/fl.R
UBCRM/R/Ll.R
UBCRM/R/Crm.R
UBCRM/R/ssimCrm.R
UBCRM/R/psil.R
UBCRM/R/ft.R
UBCRM/R/Lt.R
UBCRM/R/fp.R
UBCRM/MD5
UBCRM/DESCRIPTION
UBCRM/man
UBCRM/man/troisPtrois.Rd
UBCRM/man/Crm.Rd
UBCRM/man/aip.Rd
UBCRM/man/ssim3p3.Rd
UBCRM/man/ssimCrm.Rd
UBCRM/man/psip.Rd
UBCRM/man/updata.Rd
UBCRM/man/Lp.Rd
UBCRM/man/UBCRM-package.Rd
UBCRM/man/simCrm.Rd
UBCRM/man/fp.Rd
UBCRM/man/sim3p3.Rd
UBCRM/man/CreData.Rd