Two Phase I designs are implemented in the package: the classical 3+3 and the Continual Reassessment Method. Simulations tools are also available to estimate the operating characteristics of the methods with several user-dependent options.
|Author||Benjamin Esterni with contribution from Baboukar Mane|
|Date of publication||2015-02-20 10:31:31|
|Maintainer||Christophe Zemmour <email@example.com>|
|License||GPL (>= 2)|
aip: Functions to calculate the appropriate dose level singletons
CreData: Creates a CRM dataframe
Crm: Dose-escalation with the Continual Reassessment Method
fp: Density functions
Lp: Likelihood functions
psip: Dose-Toxicity modelisation functions
sim3p3: Simulation of one dose-escalation study with the classical...
simCrm: Simulation of one dose-escalation study with the Continual...
ssim3p3: Simulation of n dose-escalation study with the 3+3 design
ssimCrm: Simulation of n dose-escalation study with the Continual...
troisPtrois: Dose escalation with the 3+3 design
UBCRM-package: UBCRM is a package containing functions to simulate and...
updata: Update the CRM dataframe after new patients' collected data