fp: Density functions

In UBCRM: Functions to Simulate and Conduct Dose-Escalation Phase I Studies

Density functions

Description

Density functions for the model parameter. fp(a,sd) is the normal density: 1/(sd*sqrt(2*pi))*exp(-(a^2)/(2*sd^2)). ft and fl are the exponential density (with a fixed rate = 1): exp(-a).

Usage

fp(a, sd)
ft(a)
fl(a)

Arguments

a	Parameter.
sd	Standard deviation.

Value

Numeric value of the computed density.

Author(s)

Benjamin Esterni, Baboukar Mane. Unite de Biostatistique et de Methodologie, Institut Paoli-Calmettes, Marseille, France.

References

O'Quigley J., Pepe M., Fisher L. (1990). Continual Reassessment Method: a practical design for Phase I clinical trials in cancer. Biometrics 46, 33-48.

O'Quigley J., Shen LZ. (1996). Continual Reassessment Method: a likelihood approach. Biometrics 52, 673-684.

Paoletti X., Kramar A. (2009). A comparison of model choices for the Continual Reassessment Method in phase I cancer trials. Statistics in Medecine 28, 3012-3028.

Chamorey Emmanuel. (2009). Methodologie des essais de phase precoce en cancerologie: evolution des schemas et apport de la pharmacologie. These.

Garret-Mayer Elizabeth. (2006). The Continual Reassessment Method for dose-finding studies: a tutorial. Clinical Trials: 57-71.

UBCRM documentation built on May 17, 2022, 1:07 a.m.