updata | R Documentation |
This function uptdates the CRM dataframe (result of the CreData routine) with new treated patients or observed DLTs.
updata(data = data, lastdose, npt, ndlt)
data |
Dataframe to be updated. |
lastdose |
Integer representing the dose to be updated. |
npt |
Number of new treated patients. |
ndlt |
Number of DLTs among the npt patients. |
Updated dataframe.
Benjamin Esterni, Baboukar Mane. Unite de Biostatistique et de Methodologie, Institut Paoli-Calmettes, Marseille, France.
O'Quigley J., Pepe M., Fisher L. (1990). Continual Reassessment Method: a practical design for Phase I clinical trials in cancer. Biometrics 46, 33-48.
O'Quigley J., Shen LZ. (1996). Continual Reassessment Method: a likelihood approach. Biometrics 52, 673-684.
Paoletti X., Kramar A. (2009). A comparison of model choices for the Continual Reassessment Method in phase I cancer trials. Statistics in Medecine 28, 3012-3028.
Chamorey Emmanuel. (2009). Methodologie des essais de phase precoce en cancerologie: evolution des schemas et apport de la pharmacologie. These.
Garret-Mayer Elizabeth. (2006). The Continual Reassessment Method for dose-finding studies: a tutorial. Clinical Trials: 57-71.
CreData
# Study initialization data<- CreData(5,c("5 mg/m2","7 mg/m2","10 mg/m2","15 mg/m2","20 mg/m2")) data # Three patients are treated at the dose 1, without any observed DLT: data<- updata(data,lastdose=1,npt=3,ndlt=0) data
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