updata: Update the CRM dataframe after new patients' collected data

View source: R/update.R

updataR Documentation

Update the CRM dataframe after new patients' collected data

Description

This function uptdates the CRM dataframe (result of the CreData routine) with new treated patients or observed DLTs.

Usage

updata(data = data, lastdose, npt, ndlt)

Arguments

data

Dataframe to be updated.

lastdose

Integer representing the dose to be updated.

npt

Number of new treated patients.

ndlt

Number of DLTs among the npt patients.

Value

Updated dataframe.

Author(s)

Benjamin Esterni, Baboukar Mane. Unite de Biostatistique et de Methodologie, Institut Paoli-Calmettes, Marseille, France.

References

O'Quigley J., Pepe M., Fisher L. (1990). Continual Reassessment Method: a practical design for Phase I clinical trials in cancer. Biometrics 46, 33-48.

O'Quigley J., Shen LZ. (1996). Continual Reassessment Method: a likelihood approach. Biometrics 52, 673-684.

Paoletti X., Kramar A. (2009). A comparison of model choices for the Continual Reassessment Method in phase I cancer trials. Statistics in Medecine 28, 3012-3028.

Chamorey Emmanuel. (2009). Methodologie des essais de phase precoce en cancerologie: evolution des schemas et apport de la pharmacologie. These.

Garret-Mayer Elizabeth. (2006). The Continual Reassessment Method for dose-finding studies: a tutorial. Clinical Trials: 57-71.

See Also

CreData

Examples

# Study initialization
data<- CreData(5,c("5 mg/m2","7 mg/m2","10 mg/m2","15 mg/m2","20 mg/m2"))
data

# Three patients are treated at the dose 1, without any observed DLT:
data<- updata(data,lastdose=1,npt=3,ndlt=0)
data

UBCRM documentation built on May 17, 2022, 1:07 a.m.