psip: Dose-Toxicity modelisation functions

In UBCRM: Functions to Simulate and Conduct Dose-Escalation Phase I Studies

Dose-Toxicity modelisation functions

Description

psip corresponds to the power model psy(s,a)=s^exp(a). psit corresponds to the hyperbolic tangent model psy(s,a)= ((tanh(s)+1)/2)**a. psil corresponds to the logistic model psy(s,a) = exp(3+a*s)/(1+exp(3+a*s)).

Usage

psip(sgl,a)
psit(sgl,a)
psil(sgl,a)

Arguments

sgl	Dose level singleton.
a	Parameter.

Value

Numeric value of the computed function.

Author(s)

Benjamin Esterni, Baboukar Mane. Unite de Biostatistique et de Methodologie, Institut Paoli-Calmettes, Marseille, France.

References

O'Quigley J., Pepe M., Fisher L. (1990). Continual Reassessment Method: a practical design for Phase I clinical trials in cancer. Biometrics 46, 33-48.

O'Quigley J., Shen LZ. (1996). Continual Reassessment Method: a likelihood approach. Biometrics 52, 673-684.

Paoletti X., Kramar A. (2009). A comparison of model choices for the Continual Reassessment Method in phase I cancer trials. Statistics in Medecine 28, 3012-3028.

Chamorey Emmanuel. (2009). Methodologie des essais de phase precoce en cancerologie: evolution des schemas et apport de la pharmacologie. These.

Garret-Mayer Elizabeth. (2006). The Continual Reassessment Method for dose-finding studies: a tutorial. Clinical Trials: 57-71.

UBCRM documentation built on May 17, 2022, 1:07 a.m.