sim3p3: Simulation of one dose-escalation study with the classical...

In UBCRM: Functions to Simulate and Conduct Dose-Escalation Phase I Studies

Simulation of one dose-escalation study with the classical 3+3 design

Description

Given a true rates vector of DLT probabilities, the function simulate a 3+3 dose-escalation design.

Usage

sim3p3(truerate, seed = NULL)

Arguments

truerate	A nlevel-length vector of true rates for the DLTs.
seed	If not empty, the seed to use for random generation.

Value

data	Study data.
mtd	If reached, an integer representing the MTD level.
lastdose	An integer representing the last experimented dose.

Author(s)

Benjamin Esterni, Baboukar Mane. Unite de Biostatistique et de Methodologie, Institut Paoli-Calmettes, Marseille, France.

References

O'Quigley J., Pepe M., Fisher L. (1990). Continual Reassessment Method: a practical design for Phase I clinical trials in cancer. Biometrics 46, 33-48.

O'Quigley J., Shen LZ. (1996). Continual Reassessment Method: a likelihood approach. Biometrics 52, 673-684.

Paoletti X., Kramar A. (2009). A comparison of model choices for the Continual Reassessment Method in phase I cancer trials. Statistics in Medecine 28, 3012-3028.

Chamorey Emmanuel. (2009). Methodologie des essais de phase precoce en cancerologie: evolution des schemas et apport de la pharmacologie. These.

Garret-Mayer Elizabeth. (2006). The Continual Reassessment Method for dose-finding studies: a tutorial. Clinical Trials: 57-71.

See Also

troisPtrois, ssim3p3

Examples

# A 3-dose study with 10%, 20% and 30% of true rates for toxicity
sim3p3(c(0.1,0.2,0.3))

UBCRM documentation built on May 17, 2022, 1:07 a.m.