ssim3p3: Simulation of n dose-escalation study with the 3+3 design

Description Usage Arguments Value Author(s) References See Also Examples

Description

The ssim3p3 function simulates n dose-escalation study with the 3+3 design and provides summarized results.

Usage

1
ssim3p3(truerate, n, r = 2, seed = NULL)

Arguments

truerate

A nlevel-length vector of true rates for the DLTs.

n

Number of studies to simulate.

r

Integer, number of digits for percentages in output.

seed

If not empty, the seed to use for random generation.

Value

data

Summarized result in a "np1" view.

norecommendation

Percentage of studies with no recommendation for the MTD (in case of the first level is considered as toxic).

mean.npt

Mean number of enrolled patients.

mean.ndlt

Mean number of observed DLTs.

mean.lastdose

Mean last experimented dose level.

Author(s)

Benjamin Esterni, Baboukar Mane. Unite de Biostatistique et de Methodologie, Institut Paoli-Calmettes, Marseille, France.

References

O'Quigley J., Pepe M., Fisher L. (1990). Continual Reassessment Method: a practical design for Phase I clinical trials in cancer. Biometrics 46, 33-48.

O'Quigley J., Shen LZ. (1996). Continual Reassessment Method: a likelihood approach. Biometrics 52, 673-684.

Paoletti X., Kramar A. (2009). A comparison of model choices for the Continual Reassessment Method in phase I cancer trials. Statistics in Medecine 28, 3012-3028.

Chamorey Emmanuel. (2009). Methodologie des essais de phase precoce en cancerologie: evolution des schemas et apport de la pharmacologie. These.

Garret-Mayer Elizabeth. (2006). The Continual Reassessment Method for dose-finding studies: a tutorial. Clinical Trials: 57-71.

See Also

troisPtrois, sim3p3

Examples

1
ssim3p3(c(0.1,0.2,0.25,0.35),100)

Example output

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$data
       dose  npt ndlt pdlt recommendation experimentation overshoot
dose 1    1 3.72 0.37 0.10             28           31.31     68.69
dose 2    2 3.75 0.74 0.20             20           31.57     37.12
dose 3    3 2.61 0.60 0.23             26           21.97     15.15
dose 4    4 1.80 0.70 0.39             15           15.15      0.00

$norecommendation
[1] 11

$mean.npt
[1] 11.88

$mean.ndlt
[1] 2.41

$mean.lastdose
[1] 2.8

UBCRM documentation built on May 2, 2019, 10:25 a.m.