ssim3p3: Simulation of n dose-escalation study with the 3+3 design

In UBCRM: Functions to Simulate and Conduct Dose-Escalation Phase I Studies

Simulation of n dose-escalation study with the 3+3 design

Description

The ssim3p3 function simulates n dose-escalation study with the 3+3 design and provides summarized results.

Usage

ssim3p3(truerate, n, r = 2, seed = NULL)

Arguments

truerate	A nlevel-length vector of true rates for the DLTs.
n	Number of studies to simulate.
r	Integer, number of digits for percentages in output.
seed	If not empty, the seed to use for random generation.

Value

data	Summarized result in a "np1" view.
norecommendation	Percentage of studies with no recommendation for the MTD (in case of the first level is considered as toxic).
mean.npt	Mean number of enrolled patients.
mean.ndlt	Mean number of observed DLTs.
mean.lastdose	Mean last experimented dose level.

Author(s)

Benjamin Esterni, Baboukar Mane. Unite de Biostatistique et de Methodologie, Institut Paoli-Calmettes, Marseille, France.

References

O'Quigley J., Pepe M., Fisher L. (1990). Continual Reassessment Method: a practical design for Phase I clinical trials in cancer. Biometrics 46, 33-48.

O'Quigley J., Shen LZ. (1996). Continual Reassessment Method: a likelihood approach. Biometrics 52, 673-684.

Paoletti X., Kramar A. (2009). A comparison of model choices for the Continual Reassessment Method in phase I cancer trials. Statistics in Medecine 28, 3012-3028.

Chamorey Emmanuel. (2009). Methodologie des essais de phase precoce en cancerologie: evolution des schemas et apport de la pharmacologie. These.

Garret-Mayer Elizabeth. (2006). The Continual Reassessment Method for dose-finding studies: a tutorial. Clinical Trials: 57-71.

See Also

troisPtrois, sim3p3

Examples

ssim3p3(c(0.1,0.2,0.25,0.35),100)

UBCRM documentation built on May 17, 2022, 1:07 a.m.