ball_score_cll: BALL Score for Relapsed/Refractory CLL

In cliot: Clinical Indices and Outcomes Tools

BALL Score for Relapsed/Refractory CLL

Description

Calculates the BALL (Beta-2 microglobulin, Anemia, LDH, Last therapy) score to prognosticate Overall Survival in patients with relapsed or refractory Chronic Lymphocytic Leukemia (CLL). This score uses four readily available clinical variables to stratify patients into Low, Intermediate, or High risk categories.

Usage

ball_score_cll(beta2_microglobulin_mg_l, hemoglobin_g_dl, sex, ldh_elevated,
               last_therapy_pfs_lt_24mo)

Arguments

beta2_microglobulin_mg_l	Numeric. Serum Beta-2 microglobulin level in mg/L. (> 3.5 mg/L adds +1 point).
hemoglobin_g_dl	Numeric. Hemoglobin level in g/dL. Anemia (Male < 12 g/dL; Female < 11 g/dL) adds +1 point.
sex	String. Patient sex ("Male" or "Female"). Used to determine the anemia threshold.
ldh_elevated	Numeric (0 or 1). Is Lactate Dehydrogenase (LDH) greater than the Upper Limit of Normal? (1 = Yes, +1 point).
last_therapy_pfs_lt_24mo	Numeric (0 or 1). Was the duration of response (progression-free survival) to the last prior therapy < 24 months? (1 = Yes, +1 point).

Value

A list containing:

BALL_Score	The calculated score (Range 0-4).
Risk_Group	Classification (Low 0-1, Intermediate 2-3, High 4).
Est_2Yr_Overall_Survival	Estimated 2-year Overall Survival percentage based on the validation cohort.

References

Grosicki S, et al. The BALL score: a new prognostic model for relapsed/refractory chronic lymphocytic leukemia patients. Leuk Lymphoma. 2020.

Examples

# Example 1: High Risk
# B2M 5.0 (+1), Hb 10 (Male, +1), High LDH (+1), Short prior remission (+1)
# Score = 4
ball_score_cll(5.0, 10.0, "male", 1, 1)

# Example 2: Low Risk
# B2M 2.0 (0), Hb 13 (Female, 0), Normal LDH (0), Long prior remission (0)
# Score = 0
ball_score_cll(2.0, 13.0, "female", 0, 0)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.