binet_staging_cll: Binet Staging System for Chronic Lymphocytic Leukemia (CLL)

In cliot: Clinical Indices and Outcomes Tools

Binet Staging System for Chronic Lymphocytic Leukemia (CLL)

Description

Classifies Chronic Lymphocytic Leukemia (CLL) into three prognostic stages (A, B, or C) based on the number of involved lymphoid areas and the presence of anemia or thrombocytopenia.

Usage

binet_staging_cll(hemoglobin_g_dl, platelets_per_ul, cervical_nodes,
                  axillary_nodes, inguinal_nodes, liver_spleen_palpable)

Arguments

hemoglobin_g_dl	Numeric. Hemoglobin level in g/dL. (Threshold < 10 g/dL).
platelets_per_ul	Numeric. Platelet count. (Threshold < 100,000/uL).
cervical_nodes	Numeric (0 or 1). Enlargement of cervical lymph nodes. (1 = Yes).
axillary_nodes	Numeric (0 or 1). Enlargement of axillary lymph nodes. (1 = Yes).
inguinal_nodes	Numeric (0 or 1). Enlargement of inguinal lymph nodes. (1 = Yes).
liver_spleen_palpable	Numeric (0 or 1). Palpable hepatomegaly or splenomegaly. (1 = Yes).

Value

A list containing:

Binet_Stage	The calculated stage (A, B, or C).
Criteria_Description	Description of the specific criteria met.
Median_Survival	Estimated median survival based on historical data.

References

Binet JL, Auquier A, Dighiero G, et al. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer. 1981;48(1):198-206. doi:10.1002/1097-0142(19810701)48:1<198::aid-cncr2820480131>3.0.co;2-v

Examples

# Example 1: Stage C
# Hb 9.0 (Anemia), Plt 150k, 1 area involved
binet_staging_cll(9.0, 150000, 1, 0, 0, 0)

# Example 2: Stage A
# Hb 14, Plt 200k, 1 area involved (Cervical)
binet_staging_cll(14, 200000, 1, 0, 0, 0)

# Example 3: Stage B
# Hb 13, Plt 180k, 3 areas involved (Cervical, Axillary, Spleen)
binet_staging_cll(13, 180000, 1, 1, 0, 1)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.