calculate_plasma_dosage: Plasma Dosage Calculator

In cliot: Clinical Indices and Outcomes Tools

Plasma Dosage Calculator

Description

Calculates the total volume of Fresh Frozen Plasma (FFP) required based on patient weight and a specified dose per kilogram. Standard dosing for reversal of coagulopathy (e.g., warfarin reversal or elevated INR) typically ranges from 10 to 15 mL/kg, though 15 mL/kg is a common starting point.

Usage

calculate_plasma_dosage(weight_kg, dose_per_kg_ml = 15)

Arguments

weight_kg	Numeric. Patient weight in kilograms.
dose_per_kg_ml	Numeric. The desired dose of plasma in mL/kg. Defaults to 15 mL/kg, which is generally recommended for INR reversal. Ranges often cited are 10-20 mL/kg.

Details

The calculation is simply:

Total Volume (mL) = Weight (kg) \times Dose (mL/kg)

The number of units is estimated assuming an average volume of 200-250 mL per unit of FFP.

Value

A list containing:

Total_Plasma_Volume_mL	The calculated total volume of plasma in milliliters.
Estimated_Units_FFP	An estimated range of FFP units required.

References

Practice Guidelines for Blood Component Therapy: A Report by the American Society of Anesthesiologists Task Force on Blood Component Therapy. Anesthesiology. 1996;84(3):732-747. Holland LL, Brooks JP. Toward rational fresh frozen plasma transfusion: The effect of plasma transfusion on coagulation test results. Am J Clin Pathol. 2006;126(1):133-139.

Examples

# Example 1: 70kg patient, standard 15 mL/kg dose
# Volume = 70 * 15 = 1050 mL (~4-5 units)
calculate_plasma_dosage(70, 15)

# Example 2: 50kg patient, 10 mL/kg dose
# Volume = 50 * 10 = 500 mL (~2-2.5 units)
calculate_plasma_dosage(50, 10)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.