calculate_tpa_stroke_dosing: tPA (Tissue Plasminogen Activator) Dosing Calculator for...

In cliot: Clinical Indices and Outcomes Tools

tPA (Tissue Plasminogen Activator) Dosing Calculator for Stroke

Description

Calculates the recommended dosing of Alteplase (tPA) for the treatment of acute ischemic stroke. The standard dose is 0.9 mg/kg, with a maximum total dose of 90 mg. 10% of the total dose is administered as an initial bolus over 1 minute, and the remaining 90% is infused over 60 minutes.

Usage

calculate_tpa_stroke_dosing(weight_kg)

Arguments

weight_kg

Numeric. The patient's weight in kilograms.

Value

A list containing:

Total_Dose_mg	The total calculated dose (Max 90 mg).
Bolus_Dose_mg	The 10% bolus dose to be given over 1 minute.
Infusion_Dose_mg	The 90% remaining dose to be infused over 60 minutes.
Discard_Amount_from_100mg_Vial	The amount of medication to discard from a standard 100 mg vial to prevent overdose.

References

The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333(24):1581-1587. doi:10.1056/NEJM199512143332401

Examples

# Example 1: 70 kg patient
# Total = 0.9 * 70 = 63 mg
# Bolus = 6.3 mg, Infusion = 56.7 mg
calculate_tpa_stroke_dosing(70)

# Example 2: 110 kg patient (Max dose applies)
# Total = 0.9 * 110 = 99 -> Capped at 90 mg
# Bolus = 9 mg, Infusion = 81 mg
calculate_tpa_stroke_dosing(110)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.