cci_platelet_transfusion: Corrected Count Increment (CCI) for Platelet Transfusion

In cliot: Clinical Indices and Outcomes Tools

Corrected Count Increment (CCI) for Platelet Transfusion

Description

Calculates the Corrected Count Increment (CCI) to evaluate the efficacy of platelet transfusions. This metric adjusts the observed rise in platelet count for the patient's body surface area and the dose of platelets administered. It is the standard method for diagnosing platelet refractoriness.

Usage

cci_platelet_transfusion(post_platelet_count, pre_platelet_count, bsa,
                         platelets_transfused_10_11)

Arguments

post_platelet_count	Numeric. Platelet count measured 10-60 minutes after transfusion (cells/uL or /mm3).
pre_platelet_count	Numeric. Platelet count measured prior to transfusion (cells/uL or /mm3).
bsa	Numeric. Patient's Body Surface Area in m^2.
platelets_transfused_10_11	Numeric. The number of platelets transfused in units of 10^11. (e.g., for 3.0 x 10^11 platelets, enter 3.0). A typical apheresis unit contains ~3.0-4.0 x 10^11 platelets. A pooled random donor unit contains ~0.5-0.8 x 10^11 per unit.

Value

A list containing:

CCI_Value	The calculated Corrected Count Increment.
Interpretation	Clinical interpretation regarding refractoriness (typically defined as CCI < 7500 at 1 hour).

References

Hod E, Schwartz J. Platelet transfusion refractoriness. Br J Haematol. 2008;142(3):348-360. doi:10.1111/j.1365-2141.2008.07189.x

Examples

# Example 1: Successful Transfusion
# Post 40k, Pre 10k, BSA 1.8, Transfused 3.0 x 10^11
# CCI = ((40000 - 10000) * 1.8) / 3.0 = 18000
cci_platelet_transfusion(40000, 10000, 1.8, 3.0)

# Example 2: Refractory
# Post 12k, Pre 10k, BSA 2.0, Transfused 3.0 x 10^11
# CCI = ((12000 - 10000) * 2.0) / 3.0 = 1333
cci_platelet_transfusion(12000, 10000, 2.0, 3.0)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.