cdai_score: Crohn's Disease Activity Index (CDAI)

In cliot: Clinical Indices and Outcomes Tools

Crohn's Disease Activity Index (CDAI)

Description

Calculates the Crohn's Disease Activity Index (CDAI), the gold standard for assessing disease severity in clinical studies of Crohn's disease. The score is based on 8 weighted factors collected over a 7-day period, including stool frequency, pain, general well-being, and specific laboratory/clinical findings.

Usage

cdai_score(liquid_stools_sum_7d, abdominal_pain_sum_7d, well_being_sum_7d,
           complications_count, antidiarrheal_use, abdominal_mass,
           hematocrit, weight_kg, standard_weight_kg, sex)

Arguments

liquid_stools_sum_7d	Numeric. Sum of the number of liquid or soft stools for each of the last 7 days.
abdominal_pain_sum_7d	Numeric. Sum of daily abdominal pain ratings for the last 7 days (0=None, 1=Mild, 2=Moderate, 3=Severe).
well_being_sum_7d	Numeric. Sum of daily general well-being ratings for the last 7 days (0=Generally well, 1=Slightly under par, 2=Poor, 3=Very poor, 4=Terrible).
complications_count	Numeric. Count of extra-intestinal complications present (e.g., Arthritis, Iritis, Erythema nodosum, Pyoderma gangrenosum, Anal fissure/fistula, Other fistula, Fever >37.8C).
antidiarrheal_use	Numeric (0 or 1). Use of antidiarrheal drugs (e.g., loperamide) for diarrhea. (1 = Yes).
abdominal_mass	Numeric (0, 2, or 5). Physical exam finding. 0 = None, 2 = Questionable, 5 = Definite.
hematocrit	Numeric. Current Hematocrit (%). The score adds 6 points per percent deviation from standard (Male: 47, Female: 42).
weight_kg	Numeric. Current body weight in kg.
standard_weight_kg	Numeric. Standard body weight for height/sex in kg.
sex	String. "male" or "female". Used for Hematocrit standardization.

Value

A list containing:

CDAI_Score	The calculated total score (Range 0 to >600).
Disease_Activity	Classification (Remission <150, Mild 150-219, Moderate 220-450, Severe >450).

References

Best WR, Becktel JM, Singleton JW, Kern F Jr. Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology. 1976;70(3):439-444.

Examples

# Example 1: Moderate Disease
# 20 stools total (7 days), Pain sum 10, Well-being sum 10, 1 Complication,
# Antidiarrheals yes, No mass, Hct 40 (Male -> 47-40=7), Weight 70 (Std 75 -> ~6.7% dev)
# Score = (20*2) + (10*5) + (10*7) + (1*20) + 30 + 0 + (7*6) + 6.7 = ~268.7
cdai_score(20, 10, 10, 1, 1, 0, 40, 70, 75, "male")

# Example 2: Remission
# 7 stools total, Pain sum 0, Well-being sum 0, No complications, No meds,
# No mass, Hct 42 (Female -> 0), Weight 60 (Std 60 -> 0)
# Score = 14 + 0 + 0 + 0 + 0 + 0 + 0 + 0 = 14
cdai_score(7, 0, 0, 0, 0, 0, 42, 60, 60, "female")

cliot documentation built on Dec. 1, 2025, 1:06 a.m.