clif_c_aclf_score: CLIF-C ACLF Score for Acute-on-Chronic Liver Failure

In cliot: Clinical Indices and Outcomes Tools

CLIF-C ACLF Score for Acute-on-Chronic Liver Failure

Description

Calculates the CLIF-C ACLF (Consortium on Chronic Liver Failure - Acute-on-Chronic Liver Failure) score. This prognostic score is specifically designed for patients with ACLF (Acute-on-Chronic Liver Failure) to predict 28-day and 90-day mortality. It incorporates the CLIF-OF (Organ Failure) score, Age, and White Blood Cell count.

Usage

clif_c_aclf_score(age, wbc_count, bilirubin, creatinine, inr, map,
                  use_vasopressors, pao2_fio2_ratio, he_grade,
                  bilirubin_units = "mg/dL", creatinine_units = "mg/dL")

Arguments

age	Numeric. Patient age in years.
wbc_count	Numeric. White Blood Cell count in x10^9/L.
bilirubin	Numeric. Total Bilirubin level.
creatinine	Numeric. Serum Creatinine level.
inr	Numeric. International Normalized Ratio.
map	Numeric. Mean Arterial Pressure in mmHg.
use_vasopressors	Numeric (0 or 1). Is the patient on vasopressors? (1 = Yes).
pao2_fio2_ratio	Numeric. PaO2/FiO2 ratio.
he_grade	Numeric (0-4). West Haven Grade of Hepatic Encephalopathy.
bilirubin_units	String. Units for bilirubin. "mg/dL" (default) or "umol/L".
creatinine_units	String. Units for creatinine. "mg/dL" (default) or "umol/L".

Value

A list containing:

CLIF_C_ACLF_Score	The calculated prognostic score.
CLIF_OF_Score	The intermediate Organ Failure score (Sum of 6 organ system scores).
Est_28_Day_Mortality	Estimated 28-day mortality probability.
Est_90_Day_Mortality	Estimated 90-day mortality probability.

References

Jalan R, Saliba F, Pavesi M, et al. Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure. J Hepatol. 2014;61(5):1038-1047. doi:10.1016/j.jhep.2014.06.012

Examples

# Example 1: High Mortality
# Age 60, WBC 15, Bili 15, Cr 4.0, INR 3.0, Pressors Yes, PF 150, HE Grade 3
clif_c_aclf_score(60, 15, 15, 4.0, 3.0, 60, 1, 150, 3)

# Example 2: Lower Mortality
# Age 45, WBC 8, Bili 5, Cr 1.5, INR 1.5, MAP 80, No Pressors, PF 350, HE Grade 1
clif_c_aclf_score(45, 8, 5, 1.5, 1.5, 80, 0, 350, 1)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.