cp_aki_risk_score: CP-AKI Risk Calculator

In cliot: Clinical Indices and Outcomes Tools

CP-AKI Risk Calculator

Description

Calculates the Cisplatin-Associated Acute Kidney Injury (CP-AKI) Risk Score. This tool estimates the probability of developing acute kidney injury in patients undergoing treatment with intravenous cisplatin. The score incorporates patient demographics, vital signs, and laboratory values to stratify risk.

Usage

cp_aki_risk_score(age_ge_61, systolic_bp_gt_140, low_hemoglobin, low_albumin,
                  low_potassium, low_calcium, low_magnesium, high_creatinine_dose,
                  high_cisplatin_dose)

Arguments

age_ge_61	Numeric (0 or 1). Age >= 61 years. (1 = Yes, +1.5 points).
systolic_bp_gt_140	Numeric (0 or 1). Systolic Blood Pressure > 140 mmHg. (1 = Yes, +1.5 points).
low_hemoglobin	Numeric (0 or 1). Hemoglobin (Male <= 13.4 g/dL; Female <= 12.4 g/dL). (1 = Yes, +1.0 point).
low_albumin	Numeric (0 or 1). Serum Albumin <= 3.9 g/dL. (1 = Yes, +2.5 points).
low_potassium	Numeric (0 or 1). Serum Potassium <= 4.0 mmol/L. (1 = Yes, +2.0 points).
low_calcium	Numeric (0 or 1). Serum Calcium <= 9.3 mg/dL. (1 = Yes, +1.5 points).
low_magnesium	Numeric (0 or 1). Serum Magnesium <= 1.8 mg/dL. (1 = Yes, +1.5 points).
high_creatinine_dose	Numeric (0 or 1). Dose of Cisplatin per Serum Creatinine level >= 60 mg/mg. (1 = Yes, +1.5 points).
high_cisplatin_dose	Numeric (0 or 1). Dose of Cisplatin >= 50 mg. (1 = Yes, +2.5 points).

Value

A list containing:

CP_AKI_Score	The calculated risk score (Range 0-15.5).
Risk_Group	Risk classification (Low, Moderate, High).
Est_Risk_AKI	Estimated probability of developing AKI.

References

Motwani SS, et al. Development and Validation of a Risk Prediction Model for Acute Kidney Injury After the First Course of Cisplatin. J Clin Oncol. 2018.

Examples

# Example 1: High Risk
# Age 65 (+1.5), SBP 150 (+1.5), Low Alb (+2.5), High Cisplatin (+2.5)
# Score = 8.0
cp_aki_risk_score(1, 1, 0, 1, 0, 0, 0, 0, 1)

# Example 2: Low Risk
# Age 40 (0), Normal labs, Low Cisplatin Dose
# Score = 0
cp_aki_risk_score(0, 0, 0, 0, 0, 0, 0, 0, 0)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.