cryoprecipitate_dosing: Cryoprecipitate Dosing for Fibrinogen Replacement

In cliot: Clinical Indices and Outcomes Tools

Cryoprecipitate Dosing for Fibrinogen Replacement

Description

Calculates the number of cryoprecipitate units required to raise a patient's serum fibrinogen level to a specified target. The calculation estimates the patient's plasma volume based on weight and hematocrit, determines the total fibrinogen deficit, and divides by the average fibrinogen content per unit of cryoprecipitate.

Usage

cryoprecipitate_dosing(current_fibrinogen, target_fibrinogen, weight_kg,
                       hematocrit, fibrinogen_per_unit_mg = 250)

Arguments

current_fibrinogen	Numeric. Current serum fibrinogen level in mg/dL.
target_fibrinogen	Numeric. Desired serum fibrinogen level in mg/dL (typically 100-150 mg/dL depending on clinical scenario).
weight_kg	Numeric. Patient weight in kilograms.
hematocrit	Numeric. Patient hematocrit percentage (e.g., 40 for 40%). Used to estimate plasma volume.
fibrinogen_per_unit_mg	Numeric. The estimated amount of fibrinogen in a single unit of cryoprecipitate. Defaults to 250 mg (common range 200-250 mg, but can vary by blood bank).

Value

A list containing:

Estimated_Units	The calculated number of units needed, rounded up to the nearest whole unit.
Exact_Units_Calculation	The raw calculated dosage value.
Total_Fibrinogen_Required_mg	The total milligrams of fibrinogen required to meet the deficit.
Plasma_Volume_dL	The estimated plasma volume used in the calculation.

References

Nickson C. Cryoprecipitate. Life in the Fast Lane (LITFL). 2020. Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant. British Committee for Standards in Haematology. Br J Haematol. 2004;126(1):11-28.

Examples

# Example 1: 70kg patient, Hct 40, Fib 50, Target 100
# TBV = 4900 mL, PV = 2940 mL (29.4 dL)
# Deficit = 50 mg/dL * 29.4 dL = 1470 mg
# Units (at 250mg/unit) = 5.88 -> 6 Units
cryoprecipitate_dosing(50, 100, 70, 40)

# Example 2: 80kg patient, Hct 30, Fib 100, Target 150 (Higher target)
cryoprecipitate_dosing(100, 150, 80, 30)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.