hypoglycemia_risk_score: Hypoglycemia Risk Score (Karter)

In cliot: Clinical Indices and Outcomes Tools

Hypoglycemia Risk Score (Karter)

Description

Calculates the 12-month risk of severe hypoglycemia (requiring ED or hospital admission) in patients with Type 2 Diabetes. This tool, derived by Karter et al. (2017), stratifies patients into Low, Intermediate, or High risk based on prior history, medication use, renal function, age, and healthcare utilization.

Usage

hypoglycemia_risk_score(prior_hypo_episodes, insulin_use, sulfonylurea_use,
                        severe_ckd, age_years, total_ed_visits_12mo)

Arguments

prior_hypo_episodes	Numeric. Number of hypoglycemia-related ED visits or hospitalizations in the prior 12 months. 0: 0 points. 1-2: 3 points. >=3: 5 points.
insulin_use	Numeric (0 or 1). Current use of insulin. (1 = Yes, +3 points).
sulfonylurea_use	Numeric (0 or 1). Current use of sulfonylureas. (1 = Yes, +3 points).
severe_ckd	Numeric (0 or 1). Presence of severe Chronic Kidney Disease (Stage 3b, 4, 5 or eGFR < 45 mL/min). (1 = Yes, +2 points).
age_years	Numeric. Patient age in years. (< 77 years adds +2 points; >= 77 years adds 0 points). Note: Younger age in this specific older-adult cohort was associated with higher risk, potentially due to tighter glycemic control efforts.
total_ed_visits_12mo	Numeric. Total number of Emergency Department visits for *any* reason in the prior 12 months. 0: 0 points. 1: +1 point. >=2: +2 points.

Value

A list containing:

Hypoglycemia_Risk_Score	The calculated score (Range 0-17).
Risk_Level	Classification (Low <=1, Intermediate 2-6, High >=7).
Est_12_Month_Risk	Estimated percentage risk of severe hypoglycemia.

References

Karter AJ, Warton EM, Lipska KJ, et al. Development and Validation of a Tool to Identify Patients With Type 2 Diabetes at High Risk of Hypoglycemia-Related Emergency Department or Hospital Use. JAMA Intern Med. 2017;177(10):1461-1470. doi:10.1001/jamainternmed.2017.3844

Examples

# Example 1: High Risk
# 1 prior hypo (+3), Insulin (+3), Age 70 (+2), No CKD, 0 ED visits
# Score = 3 + 3 + 2 = 8
hypoglycemia_risk_score(1, 1, 0, 0, 70, 0)

# Example 2: Low Risk
# 0 prior, No Insulin, Sulfonylurea (+3), Age 80 (0), No CKD, 0 ED visits
# Score = 3 (Intermediate - wait, check thresholds: Low 0-1, Int 2-6. So Intermediate).
hypoglycemia_risk_score(0, 0, 1, 0, 80, 0)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.