icc_pmf_criteria: ICC Diagnostic Criteria for Primary Myelofibrosis (PMF)

In cliot: Clinical Indices and Outcomes Tools

ICC Diagnostic Criteria for Primary Myelofibrosis (PMF)

Description

Evaluates the International Consensus Classification (ICC) diagnostic criteria for Primary Myelofibrosis (PMF). Diagnosis requires meeting all 3 Major criteria and at least 1 Minor criterion. This applies to both Prefibrotic/Early PMF and Overt PMF (though specific histologic features differ between the two, the checklist structure is shared).

Usage

icc_pmf_criteria(histology_consistent, exclusion_of_other_neoplasms,
                 clonal_marker_present, anemia, leukocytosis, splenomegaly,
                 ldh_elevated, leukoerythroblastosis)

Arguments

histology_consistent	Numeric (0 or 1). Major Criterion: Megakaryocytic proliferation with atypia and either reticulin/collagen fibrosis (grades 2-3 for Overt) or granulocytic proliferation with decreased erythropoiesis (for Prefibrotic). (1 = Yes).
exclusion_of_other_neoplasms	Numeric (0 or 1). Major Criterion: Not meeting WHO/ICC criteria for CML, PV, ET, MDS, or other myeloid neoplasm. (1 = Yes).
clonal_marker_present	Numeric (0 or 1). Major Criterion: Presence of JAK2, CALR, or MPL mutation; OR presence of another clonal marker (e.g., ASXL1, EZH2, TET2, IDH1/IDH2, SRSF2, SF3B1); OR absence of reactive reticulin fibrosis. (1 = Yes).
anemia	Numeric (0 or 1). Minor Criterion: Anemia not attributed to a comorbid condition. (1 = Yes).
leukocytosis	Numeric (0 or 1). Minor Criterion: Leukocytosis (WBC >= 11 x 10^9/L). (1 = Yes).
splenomegaly	Numeric (0 or 1). Minor Criterion: Palpable splenomegaly. (1 = Yes).
ldh_elevated	Numeric (0 or 1). Minor Criterion: LDH level above the upper limit of normal. (1 = Yes).
leukoerythroblastosis	Numeric (0 or 1). Minor Criterion: Leukoerythroblastosis. (1 = Yes).

Value

A list containing:

Diagnosis	"Criteria Met for Primary Myelofibrosis (PMF)" or "Criteria Not Met".
Major_Criteria_Met	Count of major criteria satisfied (Max 3).
Minor_Criteria_Met	Count of minor criteria satisfied.

References

Arber DA, Orazi A, Hasserjian RP, et al. International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data. Blood. 2022;140(11):1200-1228. doi:10.1182/blood.2022015850

Examples

# Example 1: Diagnosis Met
# Histology (1), No CML/PV (1), JAK2+ (1), Anemia (1)
icc_pmf_criteria(1, 1, 1, 1, 0, 0, 0, 0)

# Example 2: Diagnosis Not Met
# Histology (1), No CML/PV (1), No Clonal Marker (0), No Minor Signs
icc_pmf_criteria(1, 1, 0, 0, 0, 0, 0, 0)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.