intrauterine_rbc_transfusion: Intrauterine RBC Transfusion Dosage

In cliot: Clinical Indices and Outcomes Tools

Intrauterine RBC Transfusion Dosage

Description

Calculates the volume of donor red blood cells (RBC) required for an intrauterine transfusion to treat fetal anemia. The calculation estimates the feto-placental blood volume based on fetal weight and uses the hematocrit difference to determine the necessary volume.

Usage

intrauterine_rbc_transfusion(fetal_weight_grams, current_hematocrit,
                             target_hematocrit, donor_hematocrit = 80)

Arguments

fetal_weight_grams	Numeric. Estimated fetal weight in grams.
current_hematocrit	Numeric. Current fetal hematocrit (pre-transfusion) percentage.
target_hematocrit	Numeric. Desired post-transfusion hematocrit percentage (typically 40-50%).
donor_hematocrit	Numeric. Hematocrit of the donor RBC unit. Defaults to 80% (typical for packed RBCs prepared for IUT).

Details

Formula:

Volume_{transfuse} = V_{feto-placental} \times \frac{Hct_{target} - Hct_{current}}{Hct_{donor} - Hct_{current}}

Where V_{feto-placental} is estimated as Weight_{fetal} \times 0.14.

Value

A list containing:

Volume_to_Transfuse_mL	The calculated volume of donor blood to administer.
Estimated_FetoPlacental_Volume_mL	The estimated total blood volume of the fetus and placenta.

References

Mandelbrot L, Daffos F, Forestier F, et al. Assessment of fetal blood volume for computer-assisted management of in utero transfusion. Fetal Diagn Ther. 1988;3(1):60-66. doi:10.1159/000263338

Examples

# Example 1: Severe Anemia
# 1000g fetus, Hct 20 -> 45, Donor Hct 80
intrauterine_rbc_transfusion(1000, 20, 45, 80)

# Example 2: Moderate Anemia
# 1500g fetus, Hct 30 -> 45, Donor Hct 75
intrauterine_rbc_transfusion(1500, 30, 45, 75)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.