iota_simple_rules_risk: IOTA Simple Rules Risk Assessment for Ovarian Tumors

In cliot: Clinical Indices and Outcomes Tools

IOTA Simple Rules Risk Assessment for Ovarian Tumors

Description

Calculates the estimated risk of malignancy for adnexal masses using the International Ovarian Tumor Analysis (IOTA) Simple Rules Risk (SRR) model. This model applies a logistic regression to the 10 standard IOTA Simple Rules features to provide a specific probability of malignancy, even when the standard rules classification is "Inconclusive".

Usage

iota_simple_rules_risk(b1_unilocular, b2_solid_lt_7mm, b3_acoustic_shadows,
                       b4_smooth_multi_lt_100mm, b5_no_blood_flow,
                       m1_irregular_solid, m2_ascites, m3_four_papillary_structures,
                       m4_irregular_multi_gt_100mm, m5_strong_blood_flow)

Arguments

b1_unilocular	Numeric (0 or 1). B1: Unilocular cyst. (1 = Yes).
b2_solid_lt_7mm	Numeric (0 or 1). B2: Presence of solid components with largest diameter < 7 mm. (1 = Yes).
b3_acoustic_shadows	Numeric (0 or 1). B3: Presence of acoustic shadows. (1 = Yes).
b4_smooth_multi_lt_100mm	Numeric (0 or 1). B4: Smooth multilocular tumor with largest diameter < 100 mm. (1 = Yes).
b5_no_blood_flow	Numeric (0 or 1). B5: No blood flow (Color score 1). (1 = Yes).
m1_irregular_solid	Numeric (0 or 1). M1: Irregular solid tumor. (1 = Yes).
m2_ascites	Numeric (0 or 1). M2: Presence of ascites. (1 = Yes).
m3_four_papillary_structures	Numeric (0 or 1). M3: At least four papillary structures. (1 = Yes).
m4_irregular_multi_gt_100mm	Numeric (0 or 1). M4: Irregular multilocular solid tumor with largest diameter >= 100 mm. (1 = Yes).
m5_strong_blood_flow	Numeric (0 or 1). M5: Very strong blood flow (Color score 4). (1 = Yes).

Value

A list containing:

Risk_of_Malignancy_Percent	The estimated percentage probability that the tumor is malignant.
Original_Classification	The outcome based on the original non-risk-calculating Simple Rules (Benign, Malignant, or Inconclusive).

References

Timmerman D, Van Calster B, Testa A, et al. Predicting the risk of malignancy in adnexal masses based on the Simple Rules from the International Ovarian Tumor Analysis group. Am J Obstet Gynecol. 2016;214(4):424-437. doi:10.1016/j.ajog.2016.01.007

Examples

# Example 1: Benign (Low Risk)
# Unilocular (B1), No flow (B5), No M features
iota_simple_rules_risk(1, 0, 0, 0, 1, 0, 0, 0, 0, 0)

# Example 2: Malignant (High Risk)
# Ascites (M2), Strong flow (M5), No B features
iota_simple_rules_risk(0, 0, 0, 0, 0, 0, 1, 0, 0, 1)

# Example 3: Inconclusive (Mixed features)
# Smooth Multi <100 (B4), but Strong flow (M5)
iota_simple_rules_risk(0, 0, 0, 1, 0, 0, 0, 0, 0, 1)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.