irae_endocrine_diabetes_grading: irAE Grading for Diabetes Mellitus (Endocrine Toxicities)

In cliot: Clinical Indices and Outcomes Tools

irAE Grading for Diabetes Mellitus (Endocrine Toxicities)

Description

Calculates the CTCAE severity grade for hyperglycemia/diabetes mellitus associated with immune checkpoint inhibitor (ICPi) therapy. Grading is based on fasting glucose levels and the presence of life-threatening complications like ketoacidosis.

Usage

irae_endocrine_diabetes_grading(fasting_glucose_mg_dl, metabolic_acidosis_present,
                                insulin_dependence)

Arguments

fasting_glucose_mg_dl	Numeric. Fasting plasma glucose level in mg/dL.
metabolic_acidosis_present	Numeric (0 or 1). Presence of ketoacidosis or metabolic acidosis. (1 = Yes).
insulin_dependence	Numeric (0 or 1). Does the patient require insulin for control? (1 = Yes).

Value

A list containing:

CTCAE_Grade	The calculated adverse event grade (1-4).
Definition	Clinical description of the grade.
Management	Recommended management strategy based on ASCO guidelines.

References

Brahmer JR, Lacchetti C, Schneider BJ, et al. Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. 2018;36(17):1714-1768. doi:10.1200/JCO.2017.77.6385

Examples

# Example 1: Severe Hyperglycemia
# Glucose 400 mg/dL, No Acidosis, Needs Insulin
irae_endocrine_diabetes_grading(400, 0, 1)

# Example 2: DKA (Life-threatening)
# Glucose 600 mg/dL, Acidosis Present
irae_endocrine_diabetes_grading(600, 1, 1)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.