iss_multiple_myeloma: International Staging System (ISS) for Multiple Myeloma

In cliot: Clinical Indices and Outcomes Tools

International Staging System (ISS) for Multiple Myeloma

Description

Calculates the International Staging System (ISS) stage for multiple myeloma. This system stratifies patients into three prognostic groups based on serum beta-2 microglobulin and serum albumin levels.

Usage

iss_multiple_myeloma(beta2_microglobulin, albumin)

Arguments

beta2_microglobulin	Numeric. Serum Beta-2 Microglobulin level in mg/L.
albumin	Numeric. Serum Albumin level in g/dL.

Value

A list containing:

ISS_Stage	The calculated stage (I, II, or III).
Median_Overall_Survival	Estimated median overall survival based on the original study data.

References

Greipp PR, San Miguel J, Durie BG, et al. International staging system for multiple myeloma. J Clin Oncol. 2005;23(15):3412-3420. doi:10.1200/JCO.2005.04.242

Examples

# Example 1: Stage I (Low B2M, Normal Albumin)
# B2M 2.5, Alb 4.0
iss_multiple_myeloma(2.5, 4.0)

# Example 2: Stage III (High B2M)
# B2M 6.0, Alb 3.0
iss_multiple_myeloma(6.0, 3.0)

# Example 3: Stage II (Intermediate)
# B2M 4.0 (Between 3.5 and 5.5)
iss_multiple_myeloma(4.0, 3.5)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.