iwg2_alzheimers_criteria: IWG-2 Criteria for Alzheimer's Disease Diagnosis

In cliot: Clinical Indices and Outcomes Tools

IWG-2 Criteria for Alzheimer's Disease Diagnosis

Description

Applies the International Working Group 2 (IWG-2) criteria (2014) for the diagnosis of Alzheimer's Disease. These criteria define AD as a clinico-biological entity, requiring both a specific clinical phenotype (typical amnestic or atypical) and in vivo evidence of Alzheimer's pathology (pathophysiological biomarkers).

Usage

iwg2_alzheimers_criteria(clinical_phenotype_present,
                         pathophysiological_marker_positive,
                         autosomal_dominant_mutation_present)

Arguments

clinical_phenotype_present	Numeric (0 or 1). Presence of a specific clinical phenotype of AD (Typical Amnestic or Atypical: Posterior Cortical Atrophy, Logopenic Aphasia, Frontal Variant). (1 = Yes).
pathophysiological_marker_positive	Numeric (0 or 1). Presence of a positive pathophysiological biomarker (Low CSF Abeta42 + High Tau, or Positive Amyloid PET). (1 = Yes).
autosomal_dominant_mutation_present	Numeric (0 or 1). Presence of a proven autosomal dominant mutation (PSEN1, PSEN2, APP). (1 = Yes).

Value

A list containing:

IWG2_Diagnosis	The diagnostic category determined by the criteria.
Classification	General classification (Definite, Supported, At Risk, or Not Met).

References

Dubois B, Feldman HH, Jacova C, et al. Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. Lancet Neurol. 2014;13(6):614-629. doi:10.1016/S1474-4422(14)70090-0

Examples

# Example 1: Diagnosis Confirmed
# Phenotype present (1), Positive Biomarker (1), No mutation (0)
iwg2_alzheimers_criteria(1, 1, 0)

# Example 2: Preclinical (Asymptomatic at risk)
# No symptoms (0), Positive Biomarker (1), No mutation (0)
iwg2_alzheimers_criteria(0, 1, 0)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.