khorana_vte_score: Khorana Risk Score for Venous Thromboembolism in Cancer...

In cliot: Clinical Indices and Outcomes Tools

Khorana Risk Score for Venous Thromboembolism in Cancer Patients

Description

Calculates the Khorana Score to predict the risk of Venous Thromboembolism (VTE) in ambulatory cancer patients initiating chemotherapy. The score stratifies patients into Low, Intermediate, or High risk categories based on cancer site, platelet count, hemoglobin, leukocyte count, and BMI.

Usage

khorana_vte_score(cancer_site_risk, platelet_count, hemoglobin, wbc_count, bmi)

Arguments

cancer_site_risk	String. Risk category of the primary tumor site. "very_high": Stomach, Pancreas (+2 pts). "high": Lung, Lymphoma, Gynecologic, Bladder, Testicular (+1 pt). "low": Other sites (0 pts).
platelet_count	Numeric. Pre-chemotherapy platelet count in x10^9/L. (>= 350 adds 1 point).
hemoglobin	Numeric. Hemoglobin level in g/dL. (< 10 g/dL or use of ESAs adds 1 point).
wbc_count	Numeric. Pre-chemotherapy leukocyte count in x10^9/L. (> 11 adds 1 point).
bmi	Numeric. Body Mass Index in kg/m^2. (>= 35 adds 1 point).

Value

A list containing:

Khorana_Score	The calculated risk score (Range 0-6).
Risk_Classification	Risk group classification (Low, Intermediate, High).
Estimated_VTE_Risk	Estimated percentage risk of symptomatic VTE.

References

Khorana AA, Kuderer NM, Culakova E, Lyman GH, Francis CW. Development and validation of a predictive model for chemotherapy-associated thrombosis. Blood. 2008;111(10):4902-4907. doi:10.1182/blood-2007-10-116327

Examples

# Example 1: High Risk (Pancreas)
# Pancreas (+2), Plt 400 (+1), BMI 28 (0)
# Score = 3
khorana_vte_score("very_high", 400, 12, 8, 28)

# Example 2: Low Risk (Breast)
# Breast (Low risk site 0), Normal labs, Normal BMI
# Score = 0
khorana_vte_score("low", 250, 13, 6, 24)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.