leibovich_2018_rcc: 2018 Leibovich Model for Renal Cell Carcinoma (RCC) Prognosis

In cliot: Clinical Indices and Outcomes Tools

2018 Leibovich Model for Renal Cell Carcinoma (RCC) Prognosis

Description

Calculates the 2018 update to the Leibovich prognostic score for non-metastatic clear cell renal cell carcinoma (ccRCC). This model predicts progression-free survival (metastasis-free) and cancer-specific survival based on pathologic stages, tumor size, nuclear grade, and histologic necrosis.

The scoring stratifies patients into Low Risk (0-2 points), Intermediate Risk (3-5 points), and High Risk (>= 6 points).

Usage

leibovich_2018_rcc(t_stage, n_stage, tumor_size_cm, nuclear_grade, necrosis)

Arguments

t_stage	String. Pathologic T stage. Accepted values: "1a", "1b", "2a", "2b", "3a", "3b", "3c", "4". (Prefixes "p" or "T" are stripped automatically).
n_stage	String. Pathologic N stage. Accepted values: "Nx", "N0", "N1". (Prefixes "p" or "N" are stripped automatically).
tumor_size_cm	Numeric. Tumor size in centimeters.
nuclear_grade	Numeric. Fuhrman or ISUP nuclear grade (1, 2, 3, or 4).
necrosis	Numeric (0 or 1). Presence of histologic tumor necrosis. 0 = No, 1 = Yes.

Value

A list containing the calculated Score, the associated Risk Group, and lists for Progression/Metastasis-Free Survival and Cancer-Specific Survival probabilities at 1, 3, 5, and 10 years.

References

Leibovich BC, Lohse CM, Cheville JC, et al. Predicting Oncologic Outcomes in Renal Cell Carcinoma After Surgery. Eur Urol. 2018;73(5):772-780. doi:10.1016/j.eururo.2018.01.005

Examples

# Example 1: High Risk Patient
# pT3a, N0, 11cm tumor, Grade 4, with Necrosis
leibovich_2018_rcc("3a", "N0", 11, 4, 1)

# Example 2: Low Risk Patient
# pT1a, Nx, 4cm tumor, Grade 2, No Necrosis
leibovich_2018_rcc("T1a", "Nx", 4, 2, 0)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.