maddreys_discriminant_function: Maddrey's Discriminant Function for Alcoholic Hepatitis

In cliot: Clinical Indices and Outcomes Tools

Maddrey's Discriminant Function for Alcoholic Hepatitis

Description

Calculates Maddrey's Discriminant Function (MDF) score to assess the severity and prognosis of alcoholic hepatitis. A score of 32 or higher identifies patients with a high risk of short-term mortality who may benefit from corticosteroid therapy.

Usage

maddreys_discriminant_function(pt_patient_seconds, pt_control_seconds,
                               bilirubin, bilirubin_units = "mg/dL")

Arguments

pt_patient_seconds	Numeric. Patient's Prothrombin Time in seconds.
pt_control_seconds	Numeric. Control Prothrombin Time in seconds (typically around 12-14 seconds).
bilirubin	Numeric. Total Bilirubin level.
bilirubin_units	String. Units for bilirubin input. Options: "mg/dL" (default) or "umol/L".

Value

A list containing:

Maddrey_DF_Score	The calculated score.
Prognosis	Interpretation of severity.
Mortality_Risk	Estimated risk of short-term mortality.
Recommendation	Guidance on treatment considerations (e.g., corticosteroids).

References

Maddrey WC, Boitnott JK, Bedine MS, et al. Corticosteroid therapy of alcoholic hepatitis. Gastroenterology. 1978;75(2):193-199.

Examples

# Example 1: Severe (Score >= 32)
# PT 22s (Control 12s), Bili 10 mg/dL
# Score = 4.6*(22-12) + 10 = 56
maddreys_discriminant_function(22, 12, 10)

# Example 2: Mild
# PT 14s (Control 12s), Bili 5 mg/dL
# Score = 4.6*(14-12) + 5 = 14.2
maddreys_discriminant_function(14, 12, 5)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.