manchester_sclc_score: Manchester Score for Prognosis in Small Cell Lung Cancer...

In cliot: Clinical Indices and Outcomes Tools

Manchester Score for Prognosis in Small Cell Lung Cancer (SCLC)

Description

Calculates the Manchester Score to predict prognosis in patients with Small Cell Lung Cancer (SCLC). The score stratifies patients into Good, Intermediate, or Poor risk groups based on LDH, Sodium, Alkaline Phosphatase, Karnofsky Performance Status, Bicarbonate, and Disease Stage.

Usage

manchester_sclc_score(ldh_level, ldh_uln, sodium, alk_phos_level, alk_phos_uln,
                      kps, bicarbonate, stage_extensive)

Arguments

ldh_level	Numeric. Patient's serum Lactate Dehydrogenase level (U/L).
ldh_uln	Numeric. Laboratory Upper Limit of Normal for LDH. (Score adds 1 if LDH >= ULN).
sodium	Numeric. Serum Sodium level (mmol/L or mEq/L). (Score adds 1 if Na < 132).
alk_phos_level	Numeric. Serum Alkaline Phosphatase level (U/L).
alk_phos_uln	Numeric. Laboratory Upper Limit of Normal for Alkaline Phosphatase. (Score adds 1 if ALP >= 1.5x ULN).
kps	Numeric. Karnofsky Performance Status score (0-100). (Score adds 1 if KPS < 60).
bicarbonate	Numeric. Serum Bicarbonate (HCO3) level (mmol/L or mEq/L). (Score adds 1 if HCO3 < 24).
stage_extensive	Numeric (0 or 1). Is the disease stage Extensive? (1 = Yes, +1 point; 0 = Limited, 0 points).

Value

A list containing:

Manchester_Score	The calculated total score (Range 0-6).
Prognosis_Group	Classification (Good 0-1, Intermediate 2-3, Poor 4-6).
Median_Survival	Estimated median survival time.
Two_Year_Survival	Estimated 2-year survival percentage.

References

Cerny T, Blair V, Anderson H, et al. Pretreatment prognostic factors and scoring system in 407 small-cell lung cancer patients. Int J Cancer. 1987;39(2):146-149. doi:10.1002/ijc.2910390204

Examples

# Example 1: Good Prognosis
# Normal labs, High KPS, Limited Stage
manchester_sclc_score(150, 250, 140, 80, 120, 90, 26, 0)

# Example 2: Poor Prognosis
# High LDH, Low Na, High ALP, Low KPS, Low HCO3, Extensive Stage
# Score = 6
manchester_sclc_score(300, 250, 130, 200, 100, 50, 20, 1)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.