mcdonald_ms_criteria_2010: McDonald Criteria for Multiple Sclerosis (2010 Revision)

In cliot: Clinical Indices and Outcomes Tools

McDonald Criteria for Multiple Sclerosis (2010 Revision)

Description

Evaluates the 2010 Revised McDonald Criteria for the diagnosis of Multiple Sclerosis (MS). These criteria allow for the diagnosis of MS in patients with a first clinical demyelinating event (Clinically Isolated Syndrome) using MRI evidence to substitute for clinical dissemination in space (DIS) and/or time (DIT).

Usage

mcdonald_ms_criteria_2010(clinical_attacks, clinical_lesions, dis_demonstrated,
                          dit_demonstrated)

Arguments

clinical_attacks	Numeric. Number of clinical attacks (relapses). (1 or >=2).
clinical_lesions	Numeric. Number of lesions with objective clinical evidence. (1 or >=2).
dis_demonstrated	Numeric (0 or 1). Dissemination in Space (DIS) demonstrated by MRI (>=1 T2 lesion in >=2 of 4 MS-typical regions: periventricular, juxtacortical, infratentorial, or spinal cord). (1 = Yes).
dit_demonstrated	Numeric (0 or 1). Dissemination in Time (DIT) demonstrated by MRI (e.g., simultaneous asymptomatic gadolinium-enhancing and non-enhancing lesions, or a new T2/enhancing lesion on follow-up). (1 = Yes).

Value

A list containing:

Diagnosis	"Multiple Sclerosis (MS)" or "Criteria Not Met / Possible CIS".
Missing_Criteria	List of specific criteria (DIS or DIT) required to confirm the diagnosis.

References

Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011;69(2):292-302. doi:10.1002/ana.22366

Examples

# Example 1: Diagnosis Met (2 attacks, 1 lesion, DIS present)
mcdonald_ms_criteria_2010(2, 1, 1, 0)

# Example 2: CIS (1 attack, 1 lesion, DIS present, No DIT)
mcdonald_ms_criteria_2010(1, 1, 1, 0)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.