mekhail_motzer_score: Mekhail Extension of the Motzer Score for Metastatic RCC

In cliot: Clinical Indices and Outcomes Tools

Mekhail Extension of the Motzer Score for Metastatic RCC

Description

Calculates the Mekhail Extension of the Motzer Score (MSKCC Score) for prognosis in patients with metastatic Renal Cell Carcinoma (mRCC) who have received prior immunotherapy or chemotherapy. This model adds "Metastasis in >= 2 organs" to the original 5 Motzer risk factors.

Usage

mekhail_motzer_score(time_to_treatment_lt_1y, kps_lt_80, hemoglobin_low,
                     calcium_high, ldh_high, metastasis_sites_ge_2)

Arguments

time_to_treatment_lt_1y	Numeric (0 or 1). Time from initial diagnosis to start of systemic treatment < 1 year. (1 = Yes).
kps_lt_80	Numeric (0 or 1). Karnofsky Performance Status < 80%. (1 = Yes).
hemoglobin_low	Numeric (0 or 1). Serum hemoglobin less than the lower limit of normal. (1 = Yes).
calcium_high	Numeric (0 or 1). Corrected serum calcium > 10 mg/dL (2.5 mmol/L). (1 = Yes).
ldh_high	Numeric (0 or 1). Lactate Dehydrogenase > 1.5x Upper Limit of Normal. (1 = Yes).
metastasis_sites_ge_2	Numeric (0 or 1). Metastasis in 2 or more organs. (1 = Yes).

Value

A list containing:

Mekhail_Score	The total count of risk factors present (Range 0-6).
Risk_Group	Classification (Favorable: 0, Intermediate: 1-2, Poor: >=3).
Median_Overall_Survival	Estimated median survival time based on the validation cohort.

References

Mekhail TM, Abou-Jawde RM, Boumerhi G, et al. Validation and extension of the Memorial Sloan-Kettering prognostic factors model for survival in patients with previously treated metastatic renal cell carcinoma. J Clin Oncol. 2005;23(4):832-841. doi:10.1200/JCO.2005.05.179

Examples

# Example 1: Poor Risk
# KPS 70 (1), Anemia (1), 3 Metastatic Sites (1)
# Score = 3
mekhail_motzer_score(0, 1, 1, 0, 0, 1)

# Example 2: Favorable Risk
# No risk factors
# Score = 0
mekhail_motzer_score(0, 0, 0, 0, 0, 0)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.